OCCURRENCE OF FREE D-ASPARTIC ACID IN THE CIRCUMSOESOPHAGEAL GANGLIA OF APLYSIA-FASCIATA

被引:33
作者
DANIELLO, A [1 ]
NARDI, G [1 ]
VETERE, A [1 ]
FERGUSON, GP [1 ]
机构
[1] STN ZOOL A DOHRN, DEPT NEUROBIOL, I-80121 NAPLES, ITALY
关键词
D O I
10.1016/0024-3205(93)90235-U
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
This study reports the presence of high concentrations of free D-aspartic acid (D-Asp) in the circumoesophageal ganglia of the opisthobranch mollusc Aplysia fasciata. D-Asp was discovered using specific methods that employ Octopus D-aspartate oxidase and hog kidney D-amino acid oxidase to measure D-Asp levels. The concentration of D-Asp was 0.281 mumol/g wet tissue weight, which was 8.3% of the total free aspartic acid (D and L forms) present. No other free D-amino acids that were oxidised by D-amino acid oxidase were detected. To our knowledge the only molluscs that have previously been shown to have D-Asp within their nervous tissue are the cephalopods Octopus vulgaris, Loligo vulgaris and Sepia officinalis. In these, as in A. fasciata, no other D-amino acids were detected within the nervous tissue. The fact that free D-Asp occurs specifically in the nervous tissue of the above molluscs suggests that it may have a neurological function that is yet to be described.
引用
收藏
页码:733 / 736
页数:4
相关论文
共 17 条
  • [11] FREE D-ASPARTATE AND D-ALANINE IN NORMAL AND ALZHEIMER BRAIN
    FISHER, GH
    DANIELLO, A
    VETERE, A
    PADULA, L
    CUSANO, GP
    MAN, EH
    [J]. BRAIN RESEARCH BULLETIN, 1991, 26 (06) : 983 - 985
  • [12] FISHER GH, 1992, IN PRESS NEUROSCIENC
  • [13] KANDEL ER, 1979, BEHAVIORAL BIOL APLY
  • [14] BIOSYNTHESIS OF PEPTIDE ANTIBIOTICS
    KLEINKAUF, H
    VONDOHREN, H
    [J]. ANNUAL REVIEW OF MICROBIOLOGY, 1987, 41 : 259 - 289
  • [15] THE PRESENCE OF FREE D-AMINO ACIDS IN MOUSE-TISSUES
    NAGATA, Y
    AKINO, T
    OHNO, K
    [J]. EXPERIENTIA, 1989, 45 (04): : 330 - 332
  • [16] FREE D-AMINO ACIDS IN HUMAN-PLASMA IN RELATION TO SENESCENCE AND RENAL DISEASES
    NAGATA, Y
    AKINO, T
    OHNO, K
    KATAOKA, Y
    UEDA, T
    SAKURAI, T
    SHIROSHITA, KI
    YASUDA, T
    [J]. CLINICAL SCIENCE, 1987, 73 (01) : 105 - 108
  • [17] OCCURRENCE OF D-AMINO ACIDS IN HIGHER ORGANISMS - A SURVEY OF THE DISTRIBUTION OF D-AMINO ACIDS IN MARINE-INVERTEBRATES
    PRESTON, RL
    [J]. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY, 1987, 87 (01): : 55 - 62