ACUTE HEMODYNAMIC AND RESPIRATORY EFFECTS OF AMNIOTIC-FLUID EMBOLISM IN THE PREGNANT GOAT MODEL

被引:38
作者
HANKINS, GDV [1 ]
SNYDER, RR [1 ]
CLARK, SL [1 ]
SCHWARTZ, L [1 ]
PATTERSON, WR [1 ]
BUTZIN, CA [1 ]
机构
[1] UNIV UTAH,MED CTR,DEPT OBSTET & GYNECOL,SALT LAKE CITY,UT 84112
关键词
AMNIOTIC FLUID EMBOLISM; CENTRAL HEMODYNAMICS; PULMONARY ARTERY CATHETER; MECONIUM; PO2; PCO2;
D O I
10.1016/0002-9378(93)90355-M
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
OBJECTIVE: Our purpose was to determine the acute-phase central hemodynamic and respiratory effects of raw, filtered, filtered and boiled, and meconium-containing amniotic fluid. STUDY DESIGN: Pregnant goats (Capra hircus) in the last one third of pregnancy were given freshly collected autologous amniotic fluid in a volume of 2.5 ml/kg of body weight. Observations were then made at 10, 30, 60, 120, and 180 minutes after amniotic fluid embolism. Pulmonary artery catheters and femoral artery lung water catheters were placed for specimen and data collection. RESULTS: Marked pressor responses were observed in both the pulmonary and systemic circulations with all amniotic fluid infusions. The pressor response was similar with raw, filtered, and filtered and boiled amniotic fluid. The pressor response seen with amniotic fluid containing meconium was significantly greater than that seen with the other forms. No significant effects were observed on cardiac or respiratory function except in the meconium group, where transient left ventricular dysfunction was accompanied by an acute increase in extravascular lung water and dysoxia. CONCLUSIONS: The Capra hircus model is appropriate for the further study of amniotic fluid embolism. The acute pressor effects are transient and involve both the systemic and pulmonary circulations. Left ventricular dysfunction and dysoxia were observed only with embolism of amniotic fluid containing meconium.
引用
收藏
页码:1113 / 1130
页数:18
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