VIRULENCE OF RHODOCOCCUS-EQUI ISOLATES FROM PATIENTS WITH AND WITHOUT AIDS

被引：82

作者：

TAKAI, S ^{[1
]}

SASAKI, Y ^{[1
]}

IKEDA, T ^{[1
]}

UCHIDA, Y ^{[1
]}

TSUBAKI, S ^{[1
]}

SEKIZAKI, T ^{[1
]}

机构：

[1] NATL INST ANIM HLTH,TSUKUBA,IBARAKI 305,JAPAN

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 1994年 / 32卷 / 02期

关键词：

D O I：

10.1128/JCM.32.2.457-460.1994

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Rhodococcus equi is an emerging opportunistic pathogen of human immunodeficiency virus-infected patients. Thirty-nine isolates of R. equi from immunocompromised patients with and without AIDS were analyzed for the presence of virulence plasmid DNA, expression of 15- to 17-kDa antigens, and their pathogenicities in mice. Of the human isolates, eight contained an 85-kb virulence plasmid, expressed 15- to 17-kDa antigens, and were virulent in mice. Nineteen isolates carried cryptic plasmids of various sizes, and the remaining 12 isolates did not contain any plasmids. These 31 isolates did not express virulence-associated antigens and were not virulent in mice. The results suggested that opportunistic infections in immunocompromised patients could be caused by both virulent and avirulent R. equi strains and that the pathogenesis of R. equi infection in immunocompromised patients appears to be different from that which occurs in foals.

引用

页码：457 / 460

页数：4

共 36 条

[31] ASSOCIATION BETWEEN A LARGE PLASMID AND 15-KILODALTON TO 17-KILODALTON ANTIGENS IN VIRULENT RHODOCOCCUS-EQUI [J].