ACTION OF SECRETIN ON EXOCRINE PANCREATIC SECRETION IN VITRO

Basal pancreatic fluid and electrolyte secretion by the isolated rabbit pancreas was studied. The hormone secretin stimulated pancreatic fluid secretion, with a maximal flow stimulation of 35 (S.E.: 1.4)% occurring after addition of 480 units/liter bathing fluid. The same dose of secretin also stimulated the22Na secretion by the rabbit pancreas in vitro. An average stimulation of 39 (S.E.: 2.1)% was observed, which is equal to the stimulation of fluid secretion. These results indicate that secretin stimulates pancreatic fluid production through increasing the active sodium secretion by the pancreas. © 1969 Springer-Verlag.