FIRST SYNTHESIS OF A FULLY [N-15,C-13]BACKBONE-LABELED PEPTIDE - N-15 NMR-SPECTRUM OF CORRESPONDING LEU-ENKEPHALIN

被引：11

作者：

NYASSE, B ^{[1
]}

GREHN, L ^{[1
]}

RAGNARSSON, U ^{[1
]}

机构：

[1] UNIV UPPSALA,CTR BIOMED,DEPT BIOCHEM,S-75123 UPPSALA,SWEDEN

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1994年 / 17期

关键词：

D O I：

10.1039/c39940002005

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Leu-Enkephalin, fully labelled with C-13 and N-15 nuclei in the backbone, is prepared chemically and the corresponding heteronuclear scalar coupling parameters measured from its C-13 and N-15 NMR spectra.

引用

页码：2005 / 2006

页数：2

共 13 条

[1] BAX A, 1991, Journal of Biomolecular NMR, V1, P99, DOI 10.1007/BF01874573
[2] BYSTROV VF, 1976, PROGR NMR SPECTROSCO, V10, P41
[3] DIRECT SYNTHESIS OF N-PROTECTED CHIRAL AMINO-ACIDS FROM IMIDODICARBONATES EMPLOYING EITHER MITSUNOBU OR TRIFLATE ALKYLATION - FEASIBILITY STUDY USING LACTATE WITH PARTICULAR REFERENCE TO N-15-LABELING
DEGERBECK, F
FRANSSON, B
GREHN, L
RAGNARSSON, U
[J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1992, (02): : 245 - 253
[4] GARBAYJAUREGUIBERRY C, 1982, INT J PEPT PROT RES, V20, P443
[5] NATURAL ABUNDANCE N-15 NUCLEAR MAGNETIC-RESONANCE SPECTROSCOPY - MEDIUM EFFECTS ON N-15 CHEMICAL-SHIFTS OF SMALL PEPTIDES
GATTEGNO, D
HAWKES, GE
RANDALL, EW
[J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2, 1976, (13): : 1527 - 1531
[6] SYNTHESIS OF C-13-LABELED AND N-15-LABELED TERT-BUTOXYCARBONYL (BOC) GLYCINES AND GLYCINE AMIDES AS PRECURSORS AND SIMPLE-MODELS OF BACKBONE-LABELED PEPTIDES
GREHN, L
BONDESSON, U
PEHK, T
RAGNARSSON, U
[J]. JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1992, (18) : 1332 - 1333
[7] SYNTHESIS AND SPECTROSCOPIC PROPERTIES OF C-13- AND N-15-LABELED TERT-BUTOXYCARBONYLGLYCINES
GREHN, L
PEHK, T
RAGNARSSON, U
[J]. ACTA CHEMICA SCANDINAVICA, 1993, 47 (11): : 1107 - 1111
[8] THEORY AND PRACTICE FOR STUDIES OF PEPTIDES BY N-15 NUCLEAR MAGNETIC-RESONANCE AT NATURAL ABUNDANCE - GRAMICIDIN-S
HAWKES, GE
RANDALL, EW
BRADLEY, CH
[J]. NATURE, 1975, 257 (5529) : 767 - 772
[9] A NOVEL-APPROACH FOR SEQUENTIAL ASSIGNMENT OF H-1, C-13, AND N-15 SPECTRA OF LARGER PROTEINS - HETERONUCLEAR TRIPLE-RESONANCE 3-DIMENSIONAL NMR-SPECTROSCOPY - APPLICATION TO CALMODULIN
IKURA, M
KAY, LE
BAX, A
[J]. BIOCHEMISTRY, 1990, 29 (19) : 4659 - 4667
[10] NEW COUPLING REAGENTS IN PEPTIDE CHEMISTRY
KNORR, R
TRZECIAK, A
BANNWARTH, W
GILLESSEN, D
[J]. TETRAHEDRON LETTERS, 1989, 30 (15) : 1927 - 1930

← 1 2 →