ENHANCEMENT OF ERYTHROCYTIC ADENOSINE-DEAMINASE FOLLOWING TREATMENT OF AIDS-RELATED COMPLEX AIDS PATIENTS WITH ZIDOVUDINE

被引：4

作者：

CASOLI, C

MAGNANI, G

SCHIANCHI, C

BARCHI, E

BERTAZZONI, U

机构：

[1] CNR,IST GENET BIOCHIM EVOLUZIONIST,I-27100 PAVIA,ITALY

[2] UNIV PARMA,IST PATOL MED,I-43100 PARMA,ITALY

[3] UNIV PARMA,CATTEDRA MALATTIE INFETT,I-43100 PARMA,ITALY

来源：

AIDS | 1990年 / 4卷 / 08期

关键词：

ADA; Adenosine deaminase; Adenosine triphosphate; AIDS; AIDS-related complex; ATP; AZT; Erythrocytes; Zidovudine;

D O I：

10.1097/00002030-199008000-00012

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The levels of adenosine deaminase (ADA) were determined in the erythrocytes of 10 patients with sexually transmitted HIV-1 infection [five cases with AIDS-related complex (ARC) and five with AIDS] before and after therapy with zidovudine (azidothymidine; AZT). A linear increase in ADA activity was observed during the second and third months of zidovudine treatment, with a final increase of about threefold after 3 months of drug administration. The concentration of adenosine triphosphate (ATP) was significantly lower in the erythrocytes of the same group of patients with respect to healthy controls, and a further decrease was noted after 3 months of zidovudine treatment. The results obtained indicate that treatment of ARC/AIDS subjects with zidovudine induces metabolic changes which could be responsible for the development of anaemia, an adverse effect frequently associated with zidovudine therapy.

引用

页码：799 / 802

页数：4