MODULATION OF ION CHANNELS IN ROD PHOTORECEPTORS BY NITRIC-OXIDE

被引：179

作者：

KURENNY, DE ^{[1
]}

MOROZ, LL ^{[1
]}

TURNER, RW ^{[1
]}

SHARKEY, KA ^{[1
]}

BARNES, S ^{[1
]}

机构：

[1] BELARUSSIAN STATE UNIV, DEPT PHYSIOL, MINSK 220080, BELARUS

来源：

NEURON | 1994年 / 13卷 / 02期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/0896-6273(94)90349-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Subcellular compartments in the outer retina of the larval tiger salamander were identified as likely sites of production of nitric oxide (NO), a recently recognized intercellular messenger. NADPH diaphorase histochemistry and NO synthase immunocytochemistry labeled photoreceptor ellipsoids and the distal regions of bipolar and glial cells apposing photoreceptor inner segments, suggesting a role for NO in visual processing in the outer retina. We investigated the actions of NO on several rod photoreceptor ion channels. Application of the NO-generating compound S-nitrosocysteine increased Ca2+ channel current and a voltage-independent conductance, but had no affect on voltage-gated K+ or nonspecific cation currents. Given the steep relation between voltage-dependent Ca2+ influx and photoreceptor synaptic output, these results indicate that NO could modulate transmission of the photoresponse to second order cells.

引用

页码：315 / 324

页数：10

共 54 条

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