SEQUENCE OF A 28.6-KB REGION OF YEAST CHROMOSOME-XI INCLUDES THE FBA1 AND TOA2 GENES, AN OPEN READING FRAME (ORF) SIMILAR TO A TRANSLATIONALLY CONTROLLED TUMOR PROTEIN, ONE ORF CONTAINING MOTIFS ALSO FOUND IN PLANT-STORAGE PROTEINS AND 13 ORFS WITH WEAK OR NO HOMOLOGY TO KNOWN PROTEINS

The complete DNA sequence of cosmid clone pUKG148 comprising 28 600 base pairs was determined from an ordered set of subclones. The sequence contains 22 open reading frames longer than 100 amino acids of which five are entirely covered by other, longer reading frames. YKL054 exhibits 25% homology at the amino acid level to a number of plant storage proteins of the glutenin type, YKL056 is 40% homologous to a translationally controlled mammalian tumour protein, YKL058 (TOA2) is identical to the small subunit of transcription factor TFIIA from yeast and YKL060 is identical to the FBA1 gene also from yeast, already sequenced but not mapped to chromosome XI. The remaining 13 open reading frames show weak or no homology to known genes. The nucleotide sequence data have been deposited in the EMBL and GenBank data libraries under Accession Number X75781.