NEW RESTRICTION-ENDONUCLEASE CVIRI CLEAVES DNA AT TG/CA SEQUENCES

被引：5

作者：

JIN, AW

ZHANG, YP

XIA, YN

TRAYLOR, E

NELSON, M

VANETTEN, JL

机构：

[1] UNIV NEBRASKA,DEPT PLANT PATHOL,LINCOLN,NE 68583

[2] MEGABASE RES PROD,LINCOLN,NE 68503

[3] BIONEBRASKA INC,LINCOLN,NE 68524

来源：

NUCLEIC ACIDS RESEARCH | 1994年 / 22卷 / 19期

关键词：

D O I：

10.1093/nar/22.19.3928

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new type II restriction endonuclease, CviRI, was isolated from virus XZ-6E infected chlorella cells. CviRI is the first restriction endonuclease to recognize the sequence 5'-TGCA-3' and cleaves DNA between the G and C residues to produce blunt-end termini. Methylation of the adenine or cytosine in 5'-TGCA-3' sequences prevents CviRI cleavage. Due to its sequence specificity, CviRI may be especially useful for detecting mutant alleles of many heritable human genetic diseases.

引用

页码：3928 / 3929

页数：2

共 11 条

[1] IDENTIFICATION OF A POINT MUTATION IN THE ADENOSINE-DEAMINASE GENE RESPONSIBLE FOR IMMUNODEFICIENCY
BONTHRON, DT
MARKHAM, AF
GINSBURG, D
ORKIN, SH
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1985, 76 (02) : 894 - 897
[2] DNA POLYMORPHISM AND THE STUDY OF DISEASE ASSOCIATIONS
COOPER, DN
CLAYTON, JF
[J]. HUMAN GENETICS, 1988, 78 (04) : 299 - 312
[3] THE CPG DINUCLEOTIDE AND HUMAN GENETIC-DISEASE
COOPER, DN
YOUSSOUFIAN, H
[J]. HUMAN GENETICS, 1988, 78 (02) : 151 - 155
[4] 5-METHYLCYTOSINE REPLACING CYTOSINE IN DEOXYRIBONUCLEIC ACID OF A BACTERIOPHAGE FOR XANTHOMONAS ORYZAE
KUO, TT
HUANG, TC
TENG, MH
[J]. JOURNAL OF MOLECULAR BIOLOGY, 1968, 34 (02) : 373 - &
[5] SUBSTITUTION OF CYSTEINE FOR GLYCINE AT RESIDUE-415 OF ONE ALLELE OF THE ALPHA-1(I) CHAIN OF TYPE-I PROCOLLAGEN IN TYPE-III/IV OSTEOGENESIS IMPERFECTA
NICHOLLS, AC
OLIVER, J
RENOUF, DV
KESTON, M
POPE, FM
[J]. JOURNAL OF MEDICAL GENETICS, 1991, 28 (11) : 757 - 764
[6] TYPE-III HYPERLIPOPROTEINEMIA ASSOCIATED WITH APOLIPOPROTEIN-E PHENOTYPE-E3/3 - STRUCTURE AND GENETICS OF AN APOLIPOPROTEIN-E3 VARIANT
RALL, SC
NEWHOUSE, YM
CLARKE, HRG
WEISGRABER, KH
MCCARTHY, BJ
MAHLEY, RW
BERSOT, TP
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1989, 83 (04) : 1095 - 1101
[7] 5-METHYLCYTOSINE AS AN ENDOGENOUS MUTAGEN IN THE HUMAN LDL RECEPTOR AND P53 GENES
RIDEOUT, WM
COETZEE, GA
OLUMI, AF
JONES, PA
[J]. SCIENCE, 1990, 249 (4974) : 1288 - 1290
[8] SCRIVER K, 1989, J BIOL CHEM, V264, P3066
[9] MOLECULAR-CLONING AND CHARACTERIZATION OF THE GENE ENCODING THE ADENINE METHYLTRANSFERASE M-CVIRI FROM CHLORELLA-VIRUS XZ-6E
STEFAN, C
XIA, YN
VANETTEN, JL
[J]. NUCLEIC ACIDS RESEARCH, 1991, 19 (02) : 307 - 311
[10] RESTRICTION ENDONUCLEASE ACTIVITY INDUCED BY PBCV-1 VIRUS-INFECTION OF A CHLORELLA-LIKE GREEN-ALGA
XIA, YN
BURBANK, DE
UHER, L
RABUSSAY, D
VANETTEN, JL
[J]. MOLECULAR AND CELLULAR BIOLOGY, 1986, 6 (05) : 1430 - 1439

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