THE ROUTE OF NONENZYMATIC AND ENZYMATIC BREAKDOWN OF 5-PHOSPHORIBOSYL 1-PYROPHOSPHATE TO RIBOSE 1-PHOSPHATE

被引：9

作者：

TREMBACZ, H ^{[1
]}

JEZEWSKA, MM ^{[1
]}

机构：

[1] POLISH ACAD SCI,INST BIOCHEM & BIOPHYS,UL RAKOWIECKA 36,PL-02532 WARSAW,POLAND

来源：

BIOCHEMICAL JOURNAL | 1990年 / 271卷 / 03期

关键词：

D O I：

10.1042/bj2710621

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Spontaneous decomposition of 5-phosphoribosyl 1-pyrophosphate at pH 5.5 was established to occur as follows: 5-Phosphoribosyl 1-pyrophosphate → 5-phosphoribosyl 1,2-(cyclic)phosphate → ribose 1-phosphate → ribose. Enzymic degradation of 5-phosphoribosyl 1-pyrophosphate by alkaline phosphatase from calf intestine and by acid phosphatases from potato and Aspergillus niger was found to proceed according to this pathway within the pH range 2.5-7.4 with accumulation of ribose 1-phosphate. In the case of alkaline phosphatase, Mg2+ ions inhibit the pyrophosphorolysis of 5-phosphoribosyl 1-pyrophosphate and stimulate the hydrolysis of ribose 1-phosphate.

引用

页码：621 / 625

页数：5

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