THE INFLUENCE OF INSULIN AND SOME EXCIPIENTS USED IN NASAL INSULIN PREPARATIONS ON MUCOCILIARY CLEARANCE

被引：49

作者：

GIZURARSON, S

MARRIOTT, C

MARTIN, GP

BECHGAARD, E

机构：

[1] NOVO SYMBION,DRUG DELIVERY GRP,DK-2100 COPENHAGEN O,DENMARK

[2] BRIGHTON POLYTECH,DEPT PHARM,PHARMACEUT SCI RES GRP,BRIGHTON BN2 4GJ,E SUSSEX,ENGLAND

[3] ROYAL DANISH SCH PHARM,DEPT PHARM,DK-2100 COPENHAGEN,DENMARK

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1990年 / 65卷 / 03期

关键词：

MUCOCILIARY CLEARANCE; INSULIN; NASAL ADMINISTRATION; FROG PALATE; SURFACTANT;

D O I：

10.1016/0378-5173(90)90149-X

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The potential local toxicity to the nasal mucosa of insulin, various absorption promoters and vehicles has been tested in the frog palate model. The influence on mucociliary transport rate was used as an estimate of toxicity. Full inhibition of this rate was observed with 1% L-alpha-lysophosphatidylcholine, 1% polyoxyethylene-9-lauryl ether, 1% sodium deoxycholate and 1% sodium dihydrotaurofusidate, whereas 1% sodium glycocholate and 1% didecanoyl-L-alpha-phosphatidylcholine had no effect. 0.1% sodium dihydrotaurofusidate increased the mucociliary transport rate and the insulin formulation Novolin(R) reduced the rate slightly, but these latter effects were always reversible.

引用

页码：243 / 247

页数：5

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