CALCIUM SIGNALING AND THE TRIGGERING OF SECRETION IN ADRENAL CHROMAFFIN CELLS

被引:25
作者
CHEEK, TR
机构
[1] AFRC Laboratory of Molecular Signalling, Department of Zoology, Cambridge, CB2 3EJ, Downing Street
关键词
D O I
10.1016/0163-7258(91)90007-9
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The pivotal intracellular message for triggering catecholamine release from bovine adrenal chromaffin cells is an elevation in the concentration of cytosolic free Ca2+ ([Ca2+]i). Studies using video-imaging techniques have shown that a rise in [Ca2+]i at the cell periphery, that is due to Ca2+ entry, is the major activating signal for exocytosis. The cytoskeleton has been idendified as a major regulatory site of exocytosis, with Ca2+ -induced disruption of the cortical actin network being required in order that previously restrained granules may have access to their exocytotic sites. The Ca2+ - and phospholipid-dependent annexin protein, calpactin, has been strongly implicated in a late stage of interaction between granules and the plasma membrane by both ultrastructural and biochemical studies.
引用
收藏
页码:173 / 189
页数:17
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