SYNTHESIS AND BIOLOGICAL INVESTIGATIONS OF SOME NEW THIAZOLYLBENZIMIDAZOLES AND BENZIMIDAZOLYLTHIAZOLO[3,2-ALPHA]PYRIDINES

被引：14

作者：

RIDA, SM ^{[1
]}

HABIB, NS ^{[1
]}

BADAWEY, EAM ^{[1
]}

FAHMY, HTY ^{[1
]}

GHOZLAN, HA ^{[1
]}

机构：

[1] UNIV ALEXANDRIA,FAC SCI,DIV MICROBIOL,ALEXANDRIA,EGYPT

来源：

ARCHIV DER PHARMAZIE | 1995年 / 328卷 / 04期

关键词：

D O I：

10.1002/ardp.19953280406

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

2-[(4-Oxo-4,5-dihydrothiazol-2-yl)methyl]-1H-benzimidazole (2) was prepared through the reaction of 2-cyanomethyl-1H-benzimidazole (1) with thioglycolic acid. The syntheses of its arylidene 3 and diazo-coupled compounds 5 and the cyclization of the aforementioned thiazolylbenzimidazole to benzimidazolylthiazolo[3,2-alpha]pyridines 8 were also performed. The prepared compounds were screened for their it-vitro antibacterial, antifungal, anti-HIV, and anticancer activities: they show promising antifungal activity.

引用

页码：325 / 328

页数：4

共 26 条

[1]

ABDELRAHMAN AE, 1983, PHARMAZIE, V38, P589

[2] ASSESSMENT OF ANTI-HIV ACTIVITY OF SOME BENZIMIDAZOLYLTHIAZOLES [J].