INVESTIGATION OF THE STEREOSPECIFICITY OF CLAVAMINIC ACID SYNTHASE IN THE DESATURATION OF DIHYDROCLAVAMINIC ACID TO CLAVAMINIC ACID

被引：11

作者：

BALDWIN, JE

ADLINGTON, RM

CROUCH, NP

DRAKE, DJ

FUJISHIMA, Y

ELSON, SW

BAGGALEY, KH

机构：

[1] UNIV OXFORD,OXFORD CTR MOLEC SCI,OXFORD OX1 3QY,ENGLAND

[2] SMITHKLINE BEECHAM PHARMACEUT,CTR INVEST BASICA,E-28760 MADRID,SPAIN

[3] SMITHKLINE BEECHAM PHARMACEUT,BETCHWORTH RH3 7AJ,SURREY,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1994年 / 09期

关键词：

D O I：

10.1039/c39940001133

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Incubations of (4R)- and (4S)-[4-H-2(1)]-proclavaminic acid with clavaminic acid synthase resulted in the stereospecific removal of the deuterium and hydrogen respectively from C-4, in their conversions to clavaminic acid, suggesting an enzyme catalysed syn-elimination for the desaturation of dihydroclavaminic acid to clavaminic acid.

引用

页码：1133 / 1134

页数：2

共 19 条

[11]

ELSON SW, Patent No. 213914

[12] STEREOCHEMICAL CORRELATION OF PROCLAVAMINIC ACID AND SYNTHESES OF ERYTHRO-L-BETA-HYDROXYORNITHINE AND THREO-L-BETA-HYDROXYORNITHINE FROM AN IMPROVED VINYLGLYCINE SYNTHON [J].