ANTINOCICEPTIVE EFFECTS OF INTRATHECAL ADMINISTRATION OF ALPHA-ADRENOCEPTOR ANTAGONISTS AND CLONIDINE IN THE FORMALIN TEST IN THE MOUSE

被引：36

作者：

KANUI, TI ^{[1
]}

TJOLSEN, A ^{[1
]}

LUND, A ^{[1
]}

MJELLEMJOLY, N ^{[1
]}

HOLE, K ^{[1
]}

机构：

[1] UNIV BERGEN, DEPT PHYSIOL, N-5014 BERGEN, NORWAY

来源：

NEUROPHARMACOLOGY | 1993年 / 32卷 / 04期

关键词：

INTRATHECAL; NORADRENERGIC; NOCICEPTION; FORMALIN TEST; MICE;

D O I：

10.1016/0028-3908(93)90158-Y

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The hypothesis that the descending noradrenergic system tonically inhibits nociception at the spinal level was investigated, using the formalin test in mice. The alpha-adrenoceptor agonist clonidine (0.46 and 0.92 mug), injected intrathecally, significantly reduced licking activity in both the early and late phase of the test. The alpha1-antagonist prazosin (3.75, 7.5 and 15 mug) and the alpha2-antagonist yohimbine (7.5 mug) also significantly reduced licking activity in both phases. The smaller doses of yohimbine (1.87 and 3.75 mug) induced an insignificant reduction of licking in the early phase. Except for the largest doses of clonidine (0.92 mug), the drugs used had no effect on the general level of activity and motor performance. These results support previous findings that increased noradrenergic activity in the spinal cord inhibits nociception, however, this inhibition seems not to be tonically active. The mechanisms of the antinociceptive actions of alpha-antagonists are not clear.

引用

页码：367 / 371

页数：5

共 32 条

[11] AN ALPHA-2 RECEPTOR MEDIATES THE SELECTIVE-INHIBITION BY NORADRENALINE OF NOCICEPTIVE RESPONSES OF IDENTIFIED DORSAL HORN NEURONS [J].