REGIONALLY SELECTIVE INCREASES IN MU-OPIOID RECEPTOR DENSITY IN THE BRAINS OF SUICIDE VICTIMS

被引：121

作者：

GROSSISSEROFF, R ^{[1
]}

DILLON, KA ^{[1
]}

ISRAELI, M ^{[1
]}

BIEGON, A ^{[1
]}

机构：

[1] NYU MED CTR,DEPT PSYCHIAT,NEW YORK,NY 10016

来源：

BRAIN RESEARCH | 1990年 / 530卷 / 02期

关键词：

Auoradiography; Human brain; Opioid receptor; Suicide; [!sup]3[!/sup]H]Tyr-d-Ala-Gly-N-methyl-Phe-Gly-ol; μ-Receptor;

D O I：

10.1016/0006-8993(90)91301-V

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effect of ageing and suicide on μ opioid receptors was studied in the human brain postmortem. Quantitative autoradiography with [3H]DAGO revealed region specific increases in μ receptor density with age. Suicide was accompanied by a significant increase, up to 9-fold, in μ receptor density in the young, but not the old, subjects as compared to age-matched controls. This effect was evident in the frontal and temporal cortical gyri. Saturation binding studies with the same ligand show that the increased binding in the elderly and in the young suicides is due to an increase in receptor density (Bmax) rather than affinity (Kd). © 1990.

引用

页码：312 / 316

页数：5

共 29 条

[11] AUTORADIOGRAPHIC ANALYSIS OF [H-3] KETANSERIN BINDING IN THE HUMAN BRAIN POSTMORTEM - EFFECT OF SUICIDE [J].