TRUNCATED TYPE-II RECEPTOR FOR BMP-4 INDUCES SECONDARY AXIAL STRUCTURES IN XENOPUS EMBRYOS

被引:38
作者
ISHIKAWA, T
YOSHIOKA, H
OHUCHI, H
NOJI, S
NOHNO, T
机构
[1] Kawasaki Med Sch, DEPT PHARMACOL, KURASHIKI, OKAYAMA 70101, JAPAN
[2] Kawasaki Med Sch, DEPT BIOCHEM, KURASHIKI, OKAYAMA 70101, JAPAN
[3] UNIV TOKUSHIMA, FAC ENGN,DEPT BIOL SCI & TECHNOL, TOKUSHIMA 770, JAPAN
关键词
D O I
10.1006/bbrc.1995.2587
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
BRK-3 is a vertebrate type II receptor for BMP-4 distantly related to invertebrate type II receptors for BMP-2/BMP-4/dpp, such as daf-d, and punt. BRK-3 has a long carboxy-terminal sequence following intracellular kinase domain and is capable of forming a high-affinity complex with a type I receptor, BRK-2. To examine the role of BRK-2 + BRK-3 receptor complex in BMP signaling during early embryogenesis, the dominant-negative form of BRK-3 was ectopically expressed in the Xenopus embryos. A secondary body axis expressing the Sonic hedgehog and N-CAM genes is induced by injecting mRNA encoding truncated form of BRK-3 into ventral marginal region, implicating the BMP signaling in axial mesoderm induction. Formation of the secondary axis depends on whether the deletion extends into the kinase domain, not into the carboxy-terminal tail, suggesting that the kinase domain, but not the tail region, is essential for BMP signaling. (C) 1995 Academic Press, Inc.
引用
收藏
页码:26 / 33
页数:8
相关论文
共 35 条
[1]   NOVEL ACTIVIN RECEPTORS - DISTINCT GENES AND ALTERNATIVE MESSENGER-RNA SPLICING GENERATE A REPERTOIRE OF SERINE THREONINE KINASE RECEPTORS [J].
ATTISANO, L ;
WRANA, JL ;
CHEIFETZ, S ;
MASSAGUE, J .
CELL, 1992, 68 (01) :97-108
[2]  
BAARENDS WM, 1994, DEVELOPMENT, V120, P189
[3]   CHARACTERIZATION AND RELATIONSHIP OF DPP RECEPTORS ENCODED BY THE SAXOPHONE AND THICK VEINS GENES IN DROSOPHILA [J].
BRUMMEL, TJ ;
TWOMBLY, V ;
MARQUES, G ;
WRANA, JL ;
NEWFELD, SJ ;
ATTISANO, L ;
MASSAGUE, J ;
OCONNOR, MB ;
GELBART, WM .
CELL, 1994, 78 (02) :251-261
[4]   IDENTIFICATION OF A DROSOPHILA ACTIVIN RECEPTOR [J].
CHILDS, SR ;
WRANA, JL ;
ARORA, K ;
ATTISANO, L ;
OCONNOR, MB ;
MASSAGUE, J .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (20) :9475-9479
[5]  
DALE L, 1992, DEVELOPMENT, V115, P573
[6]   CLONING OF A TYPE-I TGF-BETA RECEPTOR AND ITS EFFECT OF TGF-BETA BINDING TO THE TYPE-II RECEPTOR [J].
EBNER, R ;
CHEN, RH ;
SHUM, L ;
LAWLER, S ;
ZIONCHECK, TF ;
LEE, A ;
LOPEZ, AR ;
DERYNCK, R .
SCIENCE, 1993, 260 (5112) :1344-1348
[7]   SONIC-HEDGEHOG, A MEMBER OF A FAMILY OF PUTATIVE SIGNALING MOLECULES, IS IMPLICATED IN THE REGULATION OF CNS POLARITY [J].
ECHELARD, Y ;
EPSTEIN, DJ ;
STJACQUES, B ;
SHEN, L ;
MOHLER, J ;
MCMAHON, JA ;
MCMAHON, AP .
CELL, 1993, 75 (07) :1417-1430
[8]   THE DAF-4 GENE ENCODES A BONE MORPHOGENETIC PROTEIN-RECEPTOR CONTROLLING C-ELEGANS DAUER LARVA DEVELOPMENT [J].
ESTEVEZ, M ;
ATTISANO, L ;
WRANA, JL ;
ALBERT, PS ;
MASSAGUE, J ;
RIDDLE, DL .
NATURE, 1993, 365 (6447) :644-649
[9]   DAF-1, A C-ELEGANS GENE CONTROLLING DAUER LARVA DEVELOPMENT, ENCODES A NOVEL RECEPTOR PROTEIN-KINASE [J].
GEORGI, LL ;
ALBERT, PS ;
RIDDLE, DL .
CELL, 1990, 61 (04) :635-645
[10]   STUDIES WITH A XENOPUS BMP RECEPTOR SUGGEST THAT VENTRAL MESODERM-INDUCING SIGNALS OVERRIDE DORSAL SIGNALS IN-VIVO [J].
GRAFF, JM ;
THIES, RS ;
SONG, JJ ;
CELESTE, AJ ;
MELTON, DA .
CELL, 1994, 79 (01) :169-179