EFFECTS OF L-TYPE CALCIUM-CHANNEL ANTAGONISTS ON THE SEROTONIN-DEPLETING ACTIONS OF MDMA IN RATS

被引：5

作者：

FINNEGAN, KT

CALDER, L

CLIKEMAN, J

WEI, SH

KARLER, R

机构：

[1] UNIV UTAH,SCH MED,VET ADM MED CTR,DEPT PSYCHIAT,PSYCHIAT SERV,SALT LAKE CITY,UT 84132

[2] UNIV UTAH,COLL PHARM,DEPT PHARMACOL & TOXICOL,SALT LAKE CITY,UT 84132

[3] UNIV UTAH,SCH MED,DEPT PHARMACOL,SALT LAKE CITY,UT 84132

来源：

BRAIN RESEARCH | 1993年 / 603卷 / 01期

关键词：

CALCIUM; NEUROTOXICITY; AMPHETAMINE; GLUTAMATE; ANTICONVULSANT; VOLTAGE-SENSITIVE CHANNEL;

D O I：

10.1016/0006-8993(93)91310-O

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The calcium channel antagonists verapamil nifedipine and flunarizine all increased the threshold for convulsions induced by N-methyl-D-aspartate in rats. By contrast, only flunarizine blocked the long-term serotonin-depleting effects of 3,4-methylenedioxymethamphetamine. Flunarizine was also the only drug that antagonized methamphetamine-induced stereotypy. These findings suggest that calcium influx through L-type channels does not participate in the neurotoxic mechanism of MDMA, and that the neuroprotective actions of flunarizine are probably related to its anti-dopaminergic activity.

引用

页码：134 / 138

页数：5

共 28 条

[1] CALCIUM-MEDIATED NEUROTOXICITY - RELATIONSHIP TO SPECIFIC CHANNEL TYPES AND ROLE IN ISCHEMIC DAMAGE [J].

CHOI, DW .

TRENDS IN NEUROSCIENCES, 1988, 11 (10) :465-469

[2]

CHOUZA C, 1986, LANCET, V1, P1303

[3]

Di Rosa A E, 1987, Funct Neurol, V2, P47

[4] N-METHYL ASPARTATE ACTIVATES VOLTAGE-DEPENDENT CALCIUM CONDUCTANCE IN RAT HIPPOCAMPAL PYRAMIDAL CELLS [J].

DINGLEDINE, R .

JOURNAL OF PHYSIOLOGY-LONDON, 1983, 343 (OCT) :385-405

[5] DIFFERENT EFFECTS OF THE CALCIUM-ANTAGONISTS NIMODIPINE AND FLUNARIZINE ON DOPAMINE METABOLISM IN THE RAT-BRAIN [J].

FADDA, F ;

GESSA, GL ;

MOSCA, E ;

STEFANINI, E .

JOURNAL OF NEURAL TRANSMISSION, 1989, 75 (03) :195-200

[6] DEXTROMETHORPHAN PROTECTS AGAINST THE NEUROTOXIC EFFECTS OF PARA-CHLOROAMPHETAMINE IN RATS [J].

FINNEGAN, KT ;

KERR, JT ;

LANGSTON, JW .

BRAIN RESEARCH, 1991, 558 (01) :109-111

[7]

FINNEGAN KT, 1990, NEUROSCI LETT, V105, P300

[8] EFFECTS OF CALCIUM-ANTAGONISTS ON BIOGENIC-AMINES IN DISCRETE BRAIN-AREAS [J].

GAGGI, R ;

GIANNI, AM .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1990, 181 (03) :187-197

[9] FLUNARIZINE - A REVIEW OF ITS PHARMACODYNAMIC AND PHARMACOKINETIC PROPERTIES AND THERAPEUTIC USE [J].

HOLMES, B ;

BROGDEN, RN ;

HEEL, RC ;

SPEIGHT, TM ;

AVERY, GS .

DRUGS, 1984, 27 (01) :6-44

[10]

JOHNSON M, 1992, J PHARMACOL EXP THER, V261, P586

← 1 2 3 →