EFFECTS OF L-TYPE CALCIUM-CHANNEL ANTAGONISTS ON THE SEROTONIN-DEPLETING ACTIONS OF MDMA IN RATS

被引：5

作者：

FINNEGAN, KT

CALDER, L

CLIKEMAN, J

WEI, SH

KARLER, R

机构：

[1] UNIV UTAH,SCH MED,VET ADM MED CTR,DEPT PSYCHIAT,PSYCHIAT SERV,SALT LAKE CITY,UT 84132

[2] UNIV UTAH,COLL PHARM,DEPT PHARMACOL & TOXICOL,SALT LAKE CITY,UT 84132

[3] UNIV UTAH,SCH MED,DEPT PHARMACOL,SALT LAKE CITY,UT 84132

来源：

BRAIN RESEARCH | 1993年 / 603卷 / 01期

关键词：

CALCIUM; NEUROTOXICITY; AMPHETAMINE; GLUTAMATE; ANTICONVULSANT; VOLTAGE-SENSITIVE CHANNEL;

D O I：

10.1016/0006-8993(93)91310-O

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The calcium channel antagonists verapamil nifedipine and flunarizine all increased the threshold for convulsions induced by N-methyl-D-aspartate in rats. By contrast, only flunarizine blocked the long-term serotonin-depleting effects of 3,4-methylenedioxymethamphetamine. Flunarizine was also the only drug that antagonized methamphetamine-induced stereotypy. These findings suggest that calcium influx through L-type channels does not participate in the neurotoxic mechanism of MDMA, and that the neuroprotective actions of flunarizine are probably related to its anti-dopaminergic activity.

引用

页码：134 / 138

页数：5

共 28 条

[11] CALCIUM-CHANNEL BLOCKERS AND EXCITATORY AMINO-ACIDS [J].