SYNTHETIC MELANIN AND FERRIC IONS PROMOTE SUPEROXIDE ANION-MEDIATED LIPID-PEROXIDATION

被引：21

作者：

SOTOMATSU, A ^{[1
]}

TANAKA, M ^{[1
]}

HIRAI, S ^{[1
]}

机构：

[1] GUNMA UNIV, SCH MED, DEPT NEUROL, MAEBASHI, GUMMA 371, JAPAN

来源：

FEBS LETTERS | 1994年 / 342卷 / 02期

关键词：

MELANIN; IRON; LIPID PEROXIDATION; SUPEROXIDE ANION;

D O I：

10.1016/0014-5793(94)80481-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this study, we demonstrate that synthetic dopa-melanin produced superoxide anions and promoted the peroxidative cleavage of phospholipids in the presence of Fe3+-ADP complexes. SOD significantly suppressed this lipid peroxidation, while catalase or sodium benzoate did not. During the reaction, MCLA-dependent chemiluminescence was detected, and this was suppressed to the control level by the addition of SOD. Melanin has been postulated to be toxic to tissues because of its interaction with redox-active paramagnetic metal ions, and these findings suggest that superoxide anion-mediated lipid peroxidation is induced by melanin in the presence of iron.

引用

页码：105 / 108

页数：4

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