BCL-2 EXPRESSION IN THE THYMUS AND PERIPHERY

被引：18

作者：

FUJII, Y ^{[1
]}

OKUMURA, M ^{[1
]}

TAKEUCHI, Y ^{[1
]}

INADA, K ^{[1
]}

NAKAHARA, K ^{[1
]}

MATSUDA, H ^{[1
]}

TSUJIMOTO, Y ^{[1
]}

机构：

[1] OSAKA UNIV, SCH MED, BIOMED RES CTR, SUITA, OSAKA 565, JAPAN

来源：

CELLULAR IMMUNOLOGY | 1994年 / 155卷 / 02期

关键词：

D O I：

10.1006/cimm.1994.1127

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Bcl-2 proto-oncogene is expressed in normal lymphoid tissues and its role has been suggested to involve the selection of B and T cells. Here we report three-color flow cytometric studies on the expression of bcl-2 protein in the thymus and periphery. Bcl-2 was expressed in the majority of T and B cells and down-regulated only in the CD1(+), CD3(-to low), CD4(+)8(+) thymocytes, and the B cells that are in cell cycle in the tonsil and lymph node. In contrast, the CD2(+), CD1(-)3(-)4(-)8(-)19(-), early T cells, and mature single positive cells in the thymus, as well as the tonsilar and lymph node T cells, irrespective of their cell cycle status, expressed bcl-2. These results are consistent with the notion that bcl-2 is down-regulated in the T and B cells that are in the process of generating new antigen receptors and subject to subsequent positive selection. (C) 1994 Academic Press, Inc.

引用

页码：335 / 344

页数：10

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