RELATION BETWEEN PLATINUM-DNA ADDUCTS AND COMPLETE REMISSION IN ADULT ACUTE NONLYMPHOCYTIC LEUKEMIA

被引：4

作者：

ARMSTRONG, SG

BROWMAN, GP

BENGER, AM

MEYER, RM

MCKAY, KL

SINGH, G

机构：

[1] MCMASTER UNIV,HAMILTON CIV HOSP,HAMILTON REG CANC CTR,ONTARIO CANC TREATMENT & RES FDN,HAMILTON L8V 5C2,ON,CANADA

[2] MCMASTER UNIV,HAMILTON CIV HOSP,HAMILTON REG CANC CTR,ONTARIO CANC TREATMENT & RES FDN,DEPT MED,HAMILTON L8V 5C2,ON,CANADA

[3] MCMASTER UNIV,HAMILTON CIV HOSP,HAMILTON REG CANC CTR,ONTARIO CANC TREATMENT & RES FDN,HAMILTON L8V 5C2,ON,CANADA

来源：

LEUKEMIA RESEARCH | 1994年 / 18卷 / 09期

关键词：

ACUTE LEUKEMIA; PLATINUM-DNA ADDUCTS; REMISSION PREDICTION;

D O I：

10.1016/0145-2126(94)90064-7

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The purpose of this study was to determine the relationship between platinum-DNA adducts in leukemic cells and the success of remission induction therapy in adult patients with acute nonlymphocytic leukemia (ANLL). Freshly isolated cells from pre-treatment bone marrow aspirates of 14 patients were incubated with cisplatin in vitro and the amount of platinum bound to DNA was determined using a competitive ELISA procedure and an antibody directed against platinum-modified DNA. Platinum-DNA adduct levels discriminated well between complete remission (CR) and remission failure (RF) patients, treated with mitoxantrone, cytosine arabinoside +/- carboplatin.

引用

页码：659 / 664

页数：6

共 39 条

[1]

ANDREWS PA, 1990, CANCER CELL-MON REV, V2, P35

[2] DAY-4 BONE-MARROW ASPIRATE FOR PREDICTION OF RESISTANCE TO INDUCTION CHEMOTHERAPY IN ACUTE MYELOID-LEUKEMIA [J].

ARCHIMBAUD, E ;

TREILLERITOUET, D ;

GUYOTAT, D ;

VIALA, JJ ;

FIERE, D .

LEUKEMIA RESEARCH, 1987, 11 (03) :281-283

[3] FACTORS INFLUENCING THE SENSITIVITY OF 2 HUMAN BLADDER-CARCINOMA CELL-LINES TO CIS-DIAMMINEDICHLORO-PLATINUM(II) [J].

BEDFORD, P ;

WALKER, MC ;

SHARMA, HL ;

PERERA, A ;

MCAULIFFE, CA ;

MASTERS, JRW ;

HILL, BT .

CHEMICO-BIOLOGICAL INTERACTIONS, 1987, 61 (01) :1-15

[4] DIFFERENTIAL EXPRESSION OF COLLATERAL SENSITIVITY OR RESISTANCE TO CISPLATIN IN HUMAN BLADDER-CARCINOMA CELL-LINES PREEXPOSED INVITRO TO EITHER X-IRRADIATION OR CISPLATIN [J].

BEDFORD, P ;

SHELLARD, SA ;

WALKER, MC ;

WHELAN, RDH ;

MASTERS, JRW ;

HILL, BT .

INTERNATIONAL JOURNAL OF CANCER, 1987, 40 (05) :681-686

[5] A PILOT-STUDY OF CARBOPLATIN AUGMENTATION THERAPY FOR PATIENTS WITH POOR RISK ACUTE NONLYMPHOCYTIC LEUKEMIA [J].

BENGER, AM ;

BROWMAN, GP ;

WALKER, IR ;

MEYER, RM ;

WILSON, WEC ;

MCBRIDE, JA .

LEUKEMIA RESEARCH, 1992, 16 (02) :159-163

[6] PROPOSALS FOR CLASSIFICATION OF ACUTE LEUKEMIAS [J].

BENNETT, JM ;

CATOVSKY, D ;

DANIEL, MT ;

FLANDRIN, G ;

GALTON, DAG ;

GRALNICK, HR ;

SULTAN, C .

BRITISH JOURNAL OF HAEMATOLOGY, 1976, 33 (04) :451-&

[7]

BENNETT JM, 1985, ANN INTERN MED, V103, P626

[8] USE OF THE DAY 6 BONE-MARROW TO ALTER REMISSION INDUCTION THERAPY IN PATIENTS WITH ACUTE MYELOID-LEUKEMIA - A LEUKEMIA INTERGROUP STUDY [J].

BROWMAN, G ;

PREISLER, H ;

RAZA, A ;

SYRACUSE, K ;

AZARNIA, N ;

BENGER, A ;

CHERVENICK, P ;

DARRIGO, P ;

DOEBLIN, T ;

GOLDBERG, J ;

GOTTLIEB, A ;

GRUNWALD, H ;

KIRSHNER, J ;

LARSON, R ;

MEYER, R ;

MILLER, K ;

PRIORE, R ;

STEIN, M ;

VOGLER, WR ;

WALKER, I ;

WILSON, WEC ;

BARCOS, M .

BRITISH JOURNAL OF HAEMATOLOGY, 1989, 71 (04) :493-497

[9]

CHAO CCK, 1991, CANCER RES, V51, P601

[10] MECHANISMS ASSOCIATED WITH THE EXPRESSION OF CISPLATIN RESISTANCE IN A HUMAN OVARIAN TUMOR-CELL LINE FOLLOWING EXPOSURE TO FRACTIONATED X-IRRADIATION INVITRO [J].

DEMPKE, WCM ;

SHELLARD, SA ;

HOSKING, LK ;

FICHTINGERSCHEPMAN, AMJ ;

HILL, BT .

CARCINOGENESIS, 1992, 13 (07) :1209-1215

← 1 2 3 4 →