RELATION BETWEEN PLATINUM-DNA ADDUCTS AND COMPLETE REMISSION IN ADULT ACUTE NONLYMPHOCYTIC LEUKEMIA

被引：4

作者：

ARMSTRONG, SG

BROWMAN, GP

BENGER, AM

MEYER, RM

MCKAY, KL

SINGH, G

机构：

[1] MCMASTER UNIV,HAMILTON CIV HOSP,HAMILTON REG CANC CTR,ONTARIO CANC TREATMENT & RES FDN,HAMILTON L8V 5C2,ON,CANADA

[2] MCMASTER UNIV,HAMILTON CIV HOSP,HAMILTON REG CANC CTR,ONTARIO CANC TREATMENT & RES FDN,DEPT MED,HAMILTON L8V 5C2,ON,CANADA

[3] MCMASTER UNIV,HAMILTON CIV HOSP,HAMILTON REG CANC CTR,ONTARIO CANC TREATMENT & RES FDN,HAMILTON L8V 5C2,ON,CANADA

来源：

LEUKEMIA RESEARCH | 1994年 / 18卷 / 09期

关键词：

ACUTE LEUKEMIA; PLATINUM-DNA ADDUCTS; REMISSION PREDICTION;

D O I：

10.1016/0145-2126(94)90064-7

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The purpose of this study was to determine the relationship between platinum-DNA adducts in leukemic cells and the success of remission induction therapy in adult patients with acute nonlymphocytic leukemia (ANLL). Freshly isolated cells from pre-treatment bone marrow aspirates of 14 patients were incubated with cisplatin in vitro and the amount of platinum bound to DNA was determined using a competitive ELISA procedure and an antibody directed against platinum-modified DNA. Platinum-DNA adduct levels discriminated well between complete remission (CR) and remission failure (RF) patients, treated with mitoxantrone, cytosine arabinoside +/- carboplatin.

引用

页码：659 / 664

页数：6

共 39 条

[21]

MASUDA H, 1990, CANCER RES, V50, P1863

[22]

MAYER RJ, 1987, SEMIN ONCOL, V14, P384

[23] PLATINUM DNA DAMAGE IN LEUKOCYTE DNA OF PATIENTS RECEIVING CARBOPLATIN AND CISPLATIN CHEMOTHERAPY, MEASURED BY ATOMIC-ABSORPTION SPECTROMETRY [J].

PARKER, RJ ;

GILL, I ;

TARONE, R ;

VIONNET, JA ;

GRUNBERG, S ;

MUGGIA, FM ;

REED, E .

CARCINOGENESIS, 1991, 12 (07) :1253-1258

[24] ACQUIRED CISPLATIN RESISTANCE IN HUMAN OVARIAN-CANCER CELLS IS ASSOCIATED WITH ENHANCED REPAIR OF CISPLATIN-DNA LESIONS AND REDUCED DRUG ACCUMULATION [J].

PARKER, RJ ;

EASTMAN, A ;

BOSTICKBRUTON, F ;

REED, E .

JOURNAL OF CLINICAL INVESTIGATION, 1991, 87 (03) :772-777

[25] ANTIBODIES ELICITED AGAINST CIS-DIAMMINEDICHLOROPLATINUM(II)-MODIFIED DNA ARE SPECIFIC FOR CIS-DIAMMINEDICHLOROPLATINUM(II)-DNA ADDUCTS FORMED INVIVO AND INVITRO [J].

POIRIER, MC ;

LIPPARD, SJ ;

ZWELLING, LA ;

USHAY, HM ;

KERRIGAN, D ;

THILL, CC ;

SANTELLA, RM ;

GRUNBERGER, D ;

YUSPA, SH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1982, 79 (21) :6443-6447

[26] RECOGNITION OF DRUG-RESISTANCE DURING REMISSION INDUCTION THERAPY FOR ACUTE NON-LYMPHOCYTIC LEUKEMIA - UTILITY OF DAY 6 BONE-MARROW BIOPSY [J].

PREISLER, H ;

BARCOS, M ;

REESE, P ;

PRIORE, RL ;

POTHIER, L .

LEUKEMIA RESEARCH, 1983, 7 (01) :67-&

[27] FAILURE OF REMISSION INDUCTION IN ACUTE MYELOCYTIC-LEUKEMIA [J].

PREISLER, HD .

MEDICAL AND PEDIATRIC ONCOLOGY, 1978, 4 (03) :275-276

[28]

REED E, 1990, CANCER RES, V50, P2256

[29]

REED E, 1993, CANCER RES, V53, P3694

[30] PLATINUM-DNA ADDUCTS IN LEUKOCYTE DNA CORRELATE WITH DISEASE RESPONSE IN OVARIAN-CANCER PATIENTS RECEIVING PLATINUM-BASED CHEMOTHERAPY [J].

REED, E ;

OZOLS, RF ;

TARONE, R ;

YUSPA, SH ;

POIRIER, MC .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (14) :5024-5028

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