STUDIES ON MECHANISM OF ACTION OF SALICYLATES .V. EFFECT OF SALICYLIC ACID ON ENZYMES INVOLVED IN MUCOPOLYSACCHARIDES SYNTHESIS

被引：41

作者：

LEE, KH

SPENCER, MR

机构：

[1] University of California School of Pharmacy, San Francisco Medical Center, San Francisco, California

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1969年 / 58卷 / 04期

关键词：

Lysosome stability—salicylate effect; Mucopolysaccharides synthesis—salicylate effect; Salicylates—action mechanism; UV spectrophotometry—analysis;

D O I：

10.1002/jps.2600580416

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Salicylic acid (SA) and acetylsalicylic acid (ASA), unlike cortisone, promote the release of lysosomal enzymes rather than protecting rat liver lysosomal membrane. Salicylic acid inhibits the oxidation of uridine‐5‐diphosphoglucose (UDPG) competitively with nicotinamide adenosine dinucleotide (NAD) and noncompetitively with UDPG. It also competitively inhibits the transferring of glucuronyl group of uridine‐5‐phosphoglucuronic acid (UDPGA) to the phenolic acceptor. The wound‐healing retardation action of salicylates is probably due mainly to its inhibitory action on mucopolysaccharide synthesis. Copyright © 1969 Wiley‐Liss, Inc., A Wiley Company

引用

页码：464 / +

页数：1

共 37 条

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