AN EXPEDITIOUS SYNTHESIS OF BIOLOGICALLY IMPORTANT MYOINOSITOL PHOSPHOROTHIOATES

被引：19

作者：

DREEF, CE ^{[1
]}

MAYR, GW ^{[1
]}

JANSZE, JP ^{[1
]}

ROELEN, HCPF ^{[1
]}

VANDERMAREL, GA ^{[1
]}

VANBOOM, JH ^{[1
]}

机构：

[1] RUHR UNIV BOCHUM,INST PHYSIOL CHEM,W-4630 BOCHUM 1,GERMANY

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1991年 / 1卷 / 05期

关键词：

D O I：

10.1016/S0960-894X(01)81033-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The myo-inositol phosphorothioates 6, 9, 12 and 17 were readily accessible from properly protected precursors by phosphitylation with N,N-diisopropyl dibenzyl phosphoramidite (1), subsequent in situ sulfurization of the intermediate phosphite triesters with phenacetyl disulfide (3), and removal of all benzyl protecting groups.

引用

页码：239 / 242

页数：4

共 25 条

[21] MOLECULAR RECOGNITION OF INOSITOL POLYPHOSPHATES BY INTRACELLULAR RECEPTORS AND METABOLIC ENZYMES [J].

NAHORSKI, SR ;

POTTER, BVL .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1989, 10 (04) :139-&

[22] RECENT ADVANCES IN THE CHEMISTRY AND BIOCHEMISTRY OF INOSITOL PHOSPHATES OF BIOLOGICAL INTEREST [J].

POTTER, BVL .

NATURAL PRODUCT REPORTS, 1990, 7 (01) :1-24

[23] STEPWISE ENZYMATIC DEPHOSPHORYLATION OF INOSITOL 1,4,5-TRISPHOSPHATE TO INOSITOL IN LIVER [J].

STOREY, DJ ;

SHEARS, SB ;

KIRK, CJ ;

MICHELL, RH .

NATURE, 1984, 312 (5992) :374-376

[24] RELEASE OF CA-2+ FROM A NONMITOCHONDRIAL INTRACELLULAR STORE IN PANCREATIC ACINAR-CELLS BY INOSITOL-1,4,5-TRISPHOSPHATE [J].

STREB, H ;

IRVINE, RF ;

BERRIDGE, MJ ;

SCHULZ, I .

NATURE, 1983, 306 (5938) :67-69

[25] A NOVEL REAGENT FOR THE SYNTHESIS OF MYOINOSITOL PHOSPHATES - N,N-DIISOPROPYL DIBENZYL PHOSPHORAMIDITE [J].

YU, KL ;

FRASERREID, B .

TETRAHEDRON LETTERS, 1988, 29 (09) :979-982

← 1 2 3 →