RADIOIMMUNOCONJUGATES IN THE DETECTION OF INFECTION AND INFLAMMATION

被引：34

作者：

CORSTENS, FHM ^{[1
]}

OYEN, WJG ^{[1
]}

BECKER, WS ^{[1
]}

机构：

[1] FRIEDRICH ALEXANDER UNIV, DEPT NUCL MED, ERLANGEN, GERMANY

来源：

SEMINARS IN NUCLEAR MEDICINE | 1993年 / 23卷 / 02期

关键词：

D O I：

10.1016/S0001-2998(05)80095-9

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Various nuclear medicine techniques are widely used to image foci of infection and inflammation. Among the relatively new radiopharmaceuticals for this purpose are radioimmunoconjugates such as labeled murine monoclonal antigranulocyte antibodies and labeled human polyclonal nonspecific immunoglobulin G. This article reviews some background information, mechanism of action, side effects, biodistribution, kinetics, results of clinical studies, and dosimetry of several radioimmunoconjugates both of murine monoclonal and human polyclonal origin. The efficacy of these agents has been demonstrated in a variety of clinical conditions. Radiolabeled immunoconjugates may emerge as convenient alternatives to the present technique of choice: in vitro blood cell labeling techniques with their inherent problems and risks. © 1993 W.B. Saunders Company. All rights reserved.

引用

页码：148 / 164

页数：17

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