PATTERN OF INTERLEUKINS IN MINIMAL-CHANGE NEPHROTIC SYNDROME OF CHILDHOOD

被引：34

作者：

SAXENA, S ^{[1
]}

MITTAL, A ^{[1
]}

ANDAL, A ^{[1
]}

机构：

[1] SAFDARJANG HOSP, DEPT PAEDIAT NEPHROL, NEW DELHI 110016, INDIA

来源：

NEPHRON | 1993年 / 65卷 / 01期

关键词：

INTERLEUKINS; LYMPHOKINES; MINIMAL-CHANGE NEPHROTIC SYNDROME;

D O I：

10.1159/000187441

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Assays of interleukin-1 (IL-1) and IL-2 were done in supernatants from phytohaemagglutinin-activated lymphocyte cultures from 10 children suffering from minimal-change nephrotic syndrome (MCNS) to assess their role in the aetiopathogenesis of this disorder. Increased levels of IL-1 and IL-2 had been found in supernatants from patients having MCNS compared with controls, suggesting a significant role of these cytokines in the immunopathogenesis of proteinuria in this syndrome.

引用

页码：56 / 61

页数：6

共 35 条

[1] DO CIRCULATING FACTORS PLAY A ROLE IN THE PATHOGENESIS OF MINIMAL CHANGE NEPHROTIC SYNDROME [J].

BAKKER, WW ;

VANLUIJK, WHJ .

PEDIATRIC NEPHROLOGY, 1989, 3 (03) :341-349

[2]

BAKKER WW, 1982, CLIN NEPHROL, V18, P165

[3]

BERTANI T, 1982, LAB INVEST, V46, P16

[4]

CHAPMAN S, 1982, CLIN NEPHROL, V18, P34

[5] ROLE OF PLATELET-ACTIVATING-FACTOR IN ADRIAMYCIN-INDUCED NEPHROPATHY IN RATS [J].

EGIDO, J ;

ROBLES, A ;

ORTIZ, A ;

RAMIREZ, F ;

GONZALEZ, E ;

MAMPASO, F ;

CRESPO, MS ;

BRAQUET, P ;

HERNANDO, L .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1987, 138 (01) :119-123

[6] AN ELECTRON MICROSCOPE STUDY OF THE GLOMERULUS IN NEPHROSIS, GLOMERULONEPHRITIS, AND LUPUS ERYTHEMATOSUS [J].

FARQUHAR, MG ;

VERNIER, RL ;

GOOD, RA .

JOURNAL OF EXPERIMENTAL MEDICINE, 1957, 106 (05) :649-&

[7] THE BIOCHEMISTRY, BIOLOGY, AND ROLE OF INTERLEUKIN-2 IN THE INDUCTION OF CYTO-TOXIC T-CELL AND ANTIBODY-FORMING B-CELL RESPONSES [J].

FARRAR, JJ ;

BENJAMIN, WR ;

HILFIKER, ML ;

HOWARD, M ;

FARRAR, WL ;

FULLERFARRAR, J .

IMMUNOLOGICAL REVIEWS, 1982, 63 :129-166

[8] PRODUCTION AND ASSAY OF THE INTERLEUKINS [J].

GEARING, AJH ;

JOHNSTONE, AP ;

THORPE, R .

JOURNAL OF IMMUNOLOGICAL METHODS, 1985, 83 (01) :1-27

[9] SERUM IMMUNOGLOBULINS IN NEPHROTIC SYNDROME - POSSIBLE CAUSE OF MINIMAL-CHANGE NEPHROTIC SYNDROME [J].

GIANGIACOMO, J ;

CLEARY, TG ;

COLE, BR ;

HOFFSTEN, P ;

ROBSON, AM .

NEW ENGLAND JOURNAL OF MEDICINE, 1975, 293 (01) :8-12

[10] LONG-TERM CULTURE OF HUMAN ANTIGEN-SPECIFIC CYTOTOXIC T-CELL LINES [J].

GILLIS, S ;

BAKER, PE ;

RUSCETTI, FW ;

SMITH, KA .

JOURNAL OF EXPERIMENTAL MEDICINE, 1978, 148 (04) :1093-1098

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