IN-VITRO SCREENING OF TRADITIONAL MEDICINES FOR ANTIHYPERTENSIVE EFFECT BASED ON INHIBITION OF THE ANGIOTENSIN-CONVERTING ENZYME (ACE)

被引：73

作者：

HANSEN, K ^{[1
]}

NYMAN, U ^{[1
]}

SMITT, UW ^{[1
]}

ADSERSEN, A ^{[1
]}

GUDIKSEN, L ^{[1
]}

RAJASEKHARAN, S ^{[1
]}

PUSHPANGADAN, P ^{[1
]}

机构：

[1] TROP BOT GARDEN & RES INST, TRIVANDRUM 695562, KERALA, INDIA

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 1995年 / 48卷 / 01期

关键词：

ANGIOTENSIN CONVERTING ENZYME; ACE; ANTIHYPERTENSIVE; DIURETIC; BIOASSAY; TRADITIONAL MEDICINE;

D O I：

10.1016/0378-8741(95)01286-M

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Traditional medicines reported to be used as anti-hypertensives or diuretics from different regions in the world (China, India and South America) have been investigated. The bioassay is based on inhibition of ACE, as measured from the enzymatic cleavage of the chromophore-fluorophore-labelled substrate dansyltriglycine into dansylglycine and diglycine. In total, 31 species have been investigated and the crude extracts from seven species inhibit the enzyme by more than 50%.

引用

页码：43 / 51

页数：9

共 33 条

[1]

[Anonymous], CHINESE HERBAL MED

[2]

BUDESINSKY M, 1980, PHYTOCHEMISTRY, V19, P2295, DOI 10.1016/S0031-9422(00)91014-8

[3] PHENACEIN - AN ANGIOTENSIN-CONVERTING ENZYME-INHIBITOR PRODUCED BY A STREPTOMYCETE .1. TAXONOMY, FERMENTATION AND BIOLOGICAL PROPERTIES [J].

BUSH, K ;

HENRY, PR ;

SOUSERWOEHLEKE, M ;

TREJO, WH ;

SLUSARCHYK, DS .

JOURNAL OF ANTIBIOTICS, 1984, 37 (11) :1308-1312

[4]

Chang C. C., 1964, ACTA PHARM SIN, V11, P42

[5] INHIBITION OF ANGIOTENSIN-I-CONVERTING ENZYME BY TETRAHYDROXYXANTHONES ISOLATED FROM TRIPTEROSPERMUM-LANCEOLATUM [J].

CHEN, CH ;

LIN, JY ;

LIN, CN ;

HSU, SY .

JOURNAL OF NATURAL PRODUCTS, 1992, 55 (05) :691-695

[6]

DING JH, MED BOTANMY

[7]

DING LS, 1986, CHUNG TSAO YAO, V17, P347

[8]

DZAU VJ, 1988, CIRCULATION, V77, P4

[9] A NEW METHOD FOR THE INVITRO SCREENING OF INHIBITORS OF ANGIOTENSIN-CONVERTING ENZYME (ACE), USING THE CHROMOPHORE-LABELED AND FLUOROPHORE-LABELED SUBSTRATE, DANSYLTRIGLYCINE [J].

ELBL, G ;

WAGNER, H .

PLANTA MEDICA, 1991, 57 (02) :137-141

[10] VALIDITY OF THE ORIENTAL MEDICINES .50. HYPOTENSIVE PRINCIPLES OF UNCARIA HOOKS [J].

ENDO, K ;

OSHIMA, Y ;

KIKUCHI, H ;

KOSHIHARA, Y ;

HIKINO, H .

PLANTA MEDICA, 1983, 49 (03) :188-190

← 1 2 3 4 →