TWITCH AND TETANUS IN MDX MOUSE MUSCLE

被引：40

作者：

QUINLAN, JG ^{[1
]}

JOHNSON, SR ^{[1
]}

MCKEE, MK ^{[1
]}

LYDEN, SP ^{[1
]}

机构：

[1] UNIV CINCINNATI,SCH MED,CINCINNATI,OH 45221

来源：

MUSCLE & NERVE | 1992年 / 15卷 / 07期

关键词：

MDX; INSITU; TWITCH; TETANUS; EXCITATION-CONTRACTION COUPLING;

D O I：

10.1002/mus.880150713

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We compared mdx and C57BL10 anterior tibial muscle force in situ (single pulse, multiple pulse, staircase, posttetanic potentiation, and fatiguing stimulation patterns) to define muscle strength, physiology, and fatigue resistance. The relatively hypertrophied mdx muscle showed: reduced strength (N/cm2), an increased twitch-tetanus ratio, and resistance to post-fatigue twitch slowing. These differences implicate altered mdx calcium regulation, and emphasize the importance of measuring both muscle function and morphology in mdx treatment trials.

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页码：837 / 842

页数：6

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