D-CYCLOSERINE REVERSES THE WORKING MEMORY IMPAIRMENT OF HIPPOCAMPAL-LESIONED RATS IN A SPATIAL-LEARNING TASK

被引：83

作者：

SCHUSTER, GM ^{[1
]}

SCHMIDT, WJ ^{[1
]}

机构：

[1] UNIV TUBINGEN,INST ZOOL,DEPT NEUROPHARMACOL,W-7400 TUBINGEN 1,GERMANY

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1992年 / 224卷 / 01期

关键词：

QUINOLINIC ACID; LEARNING DEFICIT; D-CYCLOSERINE;

D O I：

10.1016/0014-2999(92)94825-G

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

It is shown that D-cycloserine has cognition-enhancing properties in quinolinic acid hippocampal-lesioned rats. Lesioned rats had a severe impairment of working memory in an allocentric spatial reversal paradigm in the 8-arm maze, and performance could be restored with 12 mg/kg i.p. D-cycloserine, given 30 min before testing. The present findings favour the testing of D-cycloserine for clinical efficacy in patients with Alzheimer's disease with loss of pyramidal neurons and disconnected glycine-NMDA receptor activation.

引用

页码：97 / 98

页数：2

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