Epidemiology of primary Merkel cell carcinoma in the United States

被引:397
作者
Agelli, M
Clegg, LX
机构
[1] NCI, OCTR, Bethesda, MD 20892 USA
[2] NCI, Div Canc Control & Populat Sci, Bethesda, MD 20892 USA
关键词
D O I
10.1016/S0190-9622(03)02108-X
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Background: Merkel cell carcinoma (MCC) is a rare, aggressive skin cancer. Objective: We sought to describe primary MCC incidence trends, epidemiology, and predictors of survival. Methods: The population covered by the Surveillance, Epidemiology, and End Results Program was analyzed as a prospective cohort. We measured age-adjusted incidence rates (per 100,000 person-years) and effect of age, anatomic site, and stage on survival. Results: Incidence was higher in males (0.34) than in females (0.17). Cases (n = 1034) occurred mostly in whites (94%), in people older than 65 years (76%), and at the head (48%). The 5-year relative Survival was 75%, 59%, and 25% for localized, regional, and distant MCC, respectively. Female sex, limb presentation, localized disease, and younger age were positive predictors of survival. Conclusion: The highest incidence of MCC was observed in whites, males, and in people older than 65 years. Only 49% of cases were reported as localized. Better survival was associated with limb localization, early-stage disease, younger age, and female sex.
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收藏
页码:832 / 841
页数:10
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