DIRECT ELECTROCHEMICAL DETERMINATION OF PARACETAMOL IN PLASMA

被引：28

作者：

CHRISTIE, I ^{[1
]}

LEEDS, S ^{[1
]}

BAKER, M ^{[1
]}

KEEDY, F ^{[1
]}

VADGAMA, P ^{[1
]}

机构：

[1] UNIV NEWCASTLE UPON TYNE,DEPT CLIN BIOCHEM,NEWCASTLE TYNE NE2 4HH,ENGLAND

来源：

ANALYTICA CHIMICA ACTA | 1993年 / 272卷 / 01期

关键词：

VOLTAMMETRY; MEMBRANE ELECTRODES; PARACETAMOL; PLASMA;

D O I：

10.1016/0003-2670(93)80386-Y

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A simplified, reagentless method for the determination of paracetamol (0-2 mM) in plasma is described, based on the electrochemical oxidation of paracetamol. The technique has been adapted for assay in biological fluids by the use of a permselective cellulose acetate membrane, and an outer diffusion-limiting, microporous polycarbonate membrane treated with dimethyldichlorosilane to impart biocompatibility. The results obtained agreed well with those obtained by a routine enzymic method. The limit of detection is 0.1 mM paracetamol; a range of other drugs was generally without effect.

引用

页码：145 / 150

页数：6

共 15 条

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