MASSIVE DEXTROMETHORPHAN INGESTION AND ABUSE

被引:69
作者
WOLFE, TR
CARAVATI, EM
机构
[1] Division of Emergency Medicine, University of Utah School of Medicine, Salt Lake City, UT
[2] the Utah Poison Control Center, Salt Lake City, UT
关键词
DEXTROMETHORPHAN; TOXICITY; ABUSE;
D O I
10.1016/0735-6757(95)90088-8
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
A case of a 23 year-old man who was acutely intoxicated on dex tromethorphan and who was chronically addicted to the drug is described. He consumed the highest daily dose for the longest duration yet reported in the world's English language medical literature. Toxicity, abuse potential, and therapy of dextromethorphan intoxication are discussed. ((C) 1995 by W.B. Saunders Company)
引用
收藏
页码:174 / 176
页数:3
相关论文
共 32 条
[21]  
McCarthy, Some less familiar drugs of abuse, Med J Aust, 20, pp. 1078-1081, (1971)
[22]  
Szekely, Sharpe, Jaffe, Induction of phencyclidine-like behavior in rats by dextrorphan but not dextromethorphan, Pharmacol Biochem Behav, 40, pp. 381-386, (1991)
[23]  
Tortella, Pellicano, Bowery, Dextromethorphan and neuromodulation: old drug coughs up new activities, Trends Pharmacol Sci, 10, pp. 501-507, (1989)
[24]  
Pfaff, Briegel, Lamprecht, Interindividual variation in the metabolism of dextromethorphan, Int J Pharmacol, 38, pp. 618-624, (1983)
[25]  
Schmid, Bircher, Preisig, Et al., Polymorphic dextromethorphan metabolism: co-segregation of oxidative O-demethylation with debrisoquin hydroxylation, Clin Pharmacol Ther, 38, pp. 618-624, (1985)
[26]  
Hildebrand, Seifert, Reichenberger, Determination of dextromethorphan metabolizer phenotype in healthy volunteers, Eur J Clin Pharmacol, 36, pp. 315-318, (1989)
[27]  
Kintz, Mangin, Toxicological findings in a death involving dextromethorphan and terfenadine, Am J Forensic Med Pathol, 13, pp. 351-352, (1992)
[28]  
McElwee, Beltri, Medical examiner reports of dextromethorphan exposures in the drug abuse warning network, J Clin Res Pharmacoepidemiol, 5, (1991)
[29]  
Delvin, Hall, Smolinske, Et al., Toxicity from long-acting dextromethorphan preparations, Vet Hum Toxicol, 28, (1985)
[30]  
Mofenson, Caraccio, Greensher, Et al., Gastrointestinal dialysis with activated charcoal and cathartic in the treatment of adolescent intoxications, Clin Pediatr, 24, pp. 678-684, (1985)