STEREOCONTROL OF BETA-LACTAM FORMATION USING MICROWAVE IRRADIATION

被引：107

作者：

BOSE, AK ^{[1
]}

BANIK, BK ^{[1
]}

MANHAS, MS ^{[1
]}

机构：

[1] STEVENS INST TECHNOL,DEPT CHEM & CHEM ENGN,HOBOKEN,NJ 07030

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 02期

关键词：

D O I：

10.1016/0040-4039(94)02225-Z

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Formation of beta-lactams by the reaction of an acid chloride, a Schiff base and a tertiary amine seems to involve multiple pathways some of which are very fast at higher temperatures. When beta-lactam formation is conducted in open vessels in unmodified domestic microwave ovens, high level irradiation lends to preferential formation of trans beta-lactams in several cases when the Schiff base is derived from an aryl aldehyde rather than glyceraldehyde acetonide.

引用

页码：213 / 216

页数：4

共 18 条

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