EXPRESSION OF HUMAN ALPHA-1-ANTITRYPSIN USING A RECOMBINANT ADENOVIRUS VECTOR

被引：46

作者：

GILARDI, P

COURTNEY, M

PAVIRANI, A

PERRICAUDET, M

机构：

[1] INST GUSTAVE ROUSSY,F-94800 VILLEJUIF,FRANCE

[2] TRANSGENE SA,F-67082 STRASBOURG,FRANCE

来源：

FEBS LETTERS | 1990年 / 267卷 / 01期

关键词：

Antiprotease; Gene targeting: Drug delivery; in vivo; Recombinant adenovirus; Serine protease; α[!sub]1[!/sub]-Antitrypsin;

D O I：

10.1016/0014-5793(90)80287-S

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In order to improve the in vivo delivery of human proteins destined for replacement therapy, a recombinant adenovirus containing the cDNA sequence encoding human α1-antitrypsin has been constructed and shown to direct expression of the protein in the supernatant of human cell lines. © 1990.

引用

页码：60 / 62

页数：3

共 19 条

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