IMPROVED POSTHYPOXIC RECOVERY WITH A MEMBRANE-PERMEABLE CALPAIN INHIBITOR

被引：47

作者：

ARLINGHAUS, L

MEHDI, S

LEE, KS

机构：

[1] UNIV VIRGINIA,HLTH SCI CTR,DEPT NEUROL SURG,BOX 420,CHARLOTTESVILLE,VA 22908

[2] MARION MERRELL DOW RES INST,CINCINNATI,OH 45215

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1991年 / 209卷 / 1-2期

关键词：

NEUROPROTECTION; CALPAIN INHIBITOR; HYPOXIA; HIPPOCAMPAL SLICE; PROTEOLYSIS; (RAT);

D O I：

10.1016/0014-2999(91)90022-I

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In vitro hippocampal slices from adult rats were subjected to transient hypoxia in the presence of a cell-penetrating, calpain inhibitor (Cbz-Val-Phe-H; MDL-28170). The posthypoxic recovery of synaptic potentials was greatly improved in protease inhibitor-treated slices relative to control slices. These findings support a role for calcium-activated proteolysis in the process of hypoxic pathophysiology.

引用

页码：123 / 125

页数：3