DIVERSITY OF THE MECHANISMS OF RESISTANCE TO BETA-LACTAM ANTIBIOTICS

被引：27

作者：

FRERE, JM ^{[1
]}

JORIS, B ^{[1
]}

GRANIER, B ^{[1
]}

MATAGNE, A ^{[1
]}

JACOB, F ^{[1
]}

BOURGUIGNONBELLEFROID, C ^{[1
]}

机构：

[1] INST CHIM,CTR INGN PROT,B-4000 LIEGE 1,BELGIUM

来源：

RESEARCH IN MICROBIOLOGY | 1991年 / 142卷 / 06期

关键词：

BETA-LACTAM; PEPTIDASE; PENICILLIN; CELL WALL; BETA-LACTAMASE; STEADY-STATE MODEL; GRAM-NEGATIVE BACTERIA; STEADY-STATE TREATMENT; ESCHERICHIA-COLI; QUANTITATIVE RELATIONSHIP; PERMEABILITY BARRIER; KINETIC-PARAMETERS; PENICILLIN-TARGET; STREPTOMYCES R61; OUTER-MEMBRANE; AMINO-ACID;

D O I：

10.1016/0923-2508(91)90084-N

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The sensitivity of a bacterium to beta-lactam antibiotics depends upon the interplay between 3 independent factors: the sensitivity of the essential penicillin-binding enzyme(s), the quantity and properties of the beta-lactamase(s) and the diffusion barrier that the outer-membrane of Gram-negative bacteria can represent. Those three factors can be modified by mutations or by the horizontal transfer of genes or portions of genes.

引用

页码：705 / 710

页数：6

共 31 条

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