EFFECT OF MAGNESIUM LITHOSPERMATE-B IN RATS WITH SODIUM-INDUCED HYPERTENSION AND RENAL-FAILURE

被引：33

作者：

YOKOZAWA, T ^{[1
]}

LEE, TW ^{[1
]}

OURA, H ^{[1
]}

NONAKA, G ^{[1
]}

NISHIOKA, I ^{[1
]}

机构：

[1] KYUSHU UNIV,FAC PHARMACEUT SCI,FUKUOKA 812,JAPAN

来源：

NEPHRON | 1992年 / 60卷 / 04期

关键词：

MAGNESIUM LITHOSPERMATE-B; SALVIAE-MILTIORRHIZAE RADIX; BLOOD PRESSURE; SODIUM; POTASSIUM; PROSTAGLANDIN-E2; KALLIKREIN;

D O I：

10.1159/000186809

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

To evaluate the antihypertensive effect of magnesium lithospermate B isolated from Salviae miltiorrhizae radix, determinations of blood pressure and urinary excretions of sodium, potassium, prostaglandin E2 (PGE2) and kallikrein, which have been proposed to play an important role in the regulation of blood pressure. were made in rats with sodium-induced hypertension and renal failure. In rats given magnesium lithospermate B, blood pressure was significantly decreased. whereas urinary excretion of electrolytes was significantly increased. Urinary PGE2 excretion following administration of magnesium lithospermate B increased as the dose of the compound was stepped up. The activity of kallikrein in urine was also increased by the treatment. From these results, the blood pressure-lowering action of magnesium lithospermate B may be due in part to enhancement of the kallikrein-prostaglandin system.

引用

页码：460 / 465

页数：6

共 34 条

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