EFFECT OF LONG-TERM INTRARUMINAL INFUSION OF THE GLUCOSINOLATE METABOLITE ALLYL CYANIDE ON THE VOLUNTARY FOOD-INTAKE AND METABOLISM OF LAMBS

被引:17
作者
DUNCAN, AJ
MILNE, JA
机构
[1] Macaulay Land Use Research Institute, Midlothian, EH25 9RF, Roslin
关键词
GLUCOSINOLATE; NITRILE; PHYSIOLOGICAL EFFECTS; SHEEP; INTAKE; BRASSICA;
D O I
10.1002/jsfa.2740580103
中图分类号
S [农业科学];
学科分类号
09 ;
摘要
The possible role of allyl cyanide (ACN), the nitrile breakdown product of prop-2-enyl glucosinolate, in reducing the voluntary food intake (VFI) of a dried grass pellet diet in sheep was examined in a ruminal infusion experiment. Voluntary food intake of Scottish Blackface wether lambs, infused intraruminally with allyl cyanide (0 mmol day-1, C; 4.8 mmol day-1, L; 9.6 mmol day-1, H) for 9 weeks was significantly depressed (P < 0.05) on H and L treatments compared with the C treatment. Clinical indicators of liver function (plasma gamma glutamyl transpeptidase (GGTP) activity) and kidney function (plasma urea and creatine concentrations) indicated minor liver damage but no effects on renal function. Plasma GGTP activity was significantly (P < 0.05) higher in the H than in the C group. Liver cytochrome oxidase activity at the end of the infusion period was significantly lower (P < 0.05) in the H than in the C group indicating effects on cellular respiration. In general, sheep showed considerable tolerance to administration of ACN in comparison with previously demonstrated toxicity in monogastrics.
引用
收藏
页码:9 / 14
页数:6
相关论文
共 28 条
[1]   COMPARATIVE TOXICITIES OF ALIPHATIC NITRILES [J].
AHMED, AE ;
FAROOQUI, MYH .
TOXICOLOGY LETTERS, 1982, 12 (2-3) :157-163
[2]  
BEUTLER E, 1963, J LAB CLIN MED, V61, P882
[3]   GLUTATHIONE S-ARALKYLTRANSFERASE [J].
BOYLAND, E ;
CHASSEAU.LF .
BIOCHEMICAL JOURNAL, 1969, 115 (05) :985-&
[4]   JAFFE REACTION - IDENTIFICATION OF COLORED SPECIES [J].
BUTLER, AR .
CLINICA CHIMICA ACTA, 1975, 59 (02) :227-232
[5]   RUMINAL METABOLISM OF PLANT TOXINS WITH EMPHASIS ON INDOLIC COMPOUNDS [J].
CARLSON, JR ;
BREEZE, RG .
JOURNAL OF ANIMAL SCIENCE, 1984, 58 (04) :1040-1049
[6]  
COOPERSTEIN SJ, 1951, J BIOL CHEM, V189, P665
[7]  
DICKINSON JM, 1988, J ANIM SCI, V66, P1969
[8]  
DUNCAN AJ, 1990, THESIS U EDINBURGH
[9]   GLUCOSINOLATES AND THEIR BREAKDOWN PRODUCTS IN FOOD AND FOOD PLANTS [J].
FENWICK, GR ;
HEANEY, RK ;
MULLIN, WJ .
CRC CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION, 1983, 18 (02) :123-201
[10]   OBSERVATIONS ON NITRILE PRODUCTION DURING AUTOLYSIS OF KALE AND SWEDES, AND THEIR STABILITY DURING INCUBATION WITH RUMEN FLUID [J].
FORSS, DA ;
BARRY, TN .
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, 1983, 34 (10) :1077-1084