ANTIIDIOTYPIC B-LYMPHOCYTES IN PATIENTS WITH MONOCLONAL GAMMOPATHIES

被引：16

作者：

BERGENBRANT, S

YI, Q

OSBY, E

OSTERBORG, A

OSTMAN, R

BJORKHOLM, M

HOLM, G

LEFVERT, AK

机构：

[1] KAROLINSKA HOSP,DEPT INTERNAL MED,DIV HEMATOL & MED IMMUNOL,S-17176 STOCKHOLM,SWEDEN

[2] KAROLINSKA HOSP,IMMUNOL RES LAB,S-10401 STOCKHOLM,SWEDEN

[3] KAROLINSKA HOSP,DEPT ONCOL,S-10401 STOCKHOLM,SWEDEN

来源：

SCANDINAVIAN JOURNAL OF IMMUNOLOGY | 1994年 / 40卷 / 02期

关键词：

D O I：

10.1111/j.1365-3083.1994.tb03453.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The prevalence of peripheral blood B cells secreting antibodies reacting with the F(ab')(2) fragment of monoclonal Ige was studied in five patients with multiple myeloma (MM), nine patients with monoclonal gammopathy of undetermined significance (MGUS) and six healthy controls. An enzyme-linked immunospot assay allowed direct visualization of antibody producing B cells. All patients had B cells producing antibodies to autologous or allogeneic monoclonal IgG. Autoreactive cells were found more frequently than alloreactive cells in seven out of nine patients with MGUS and three out of four patients with MM. The same frequency of alloreactive cells in the patient groups was detected in healthy individuals. These findings show the existence of B cells producing anti-idiotypic antibodies which could be a part of an idiotypic network in monoclonal gammopathies.

引用

页码：216 / 220

页数：5