DISTRIBUTION AND EXCRETION OF RADIOIRON IN RAT AS INFLUENCED BY CHELATING AGENTS

The influence of various chelating agents on the distribution and excretion of radioiron, carrier-free or diluted with stable carrier, was studied in rats. Simultaneous administration of chelating agents lowers the retention of radioactive iron in all tissues whereas after delayed treatment a small fraction of storage iron can be removed from liver and spleen. The efficacy is higher in the case of isotopically diluted radioactive iron. The most effective compounds are ethylenedi-(α-o-hydroxyphenyl)glycine, 2-(β-aminoethoxy)cyclohexylaminetetraacetate, and desferrioxamine B. The practical value of the former chelator, however, is excluded by its high toxicity. © 1969 Springer-Verlag.