DISTRIBUTION AND EXCRETION OF RADIOIRON IN RAT AS INFLUENCED BY CHELATING AGENTS

被引：13

作者：

GUNTHER, R

机构：

[1] Institut für Strahlenbiologie, Kernforschungszentrum Karlsruhe

来源：

NAUNYN-SCHMIEDEBERGS ARCHIV FUR PHARMAKOLOGIE | 1969年 / 262卷 / 04期

关键词：

Chelating Agents; Isotopic Dilution; Radioactive Iron; Rat;

D O I：

10.1007/BF00537838

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The influence of various chelating agents on the distribution and excretion of radioiron, carrier-free or diluted with stable carrier, was studied in rats. Simultaneous administration of chelating agents lowers the retention of radioactive iron in all tissues whereas after delayed treatment a small fraction of storage iron can be removed from liver and spleen. The efficacy is higher in the case of isotopically diluted radioactive iron. The most effective compounds are ethylenedi-(α-o-hydroxyphenyl)glycine, 2-(β-aminoethoxy)cyclohexylaminetetraacetate, and desferrioxamine B. The practical value of the former chelator, however, is excluded by its high toxicity. © 1969 Springer-Verlag.

引用

页码：405 / &

共 32 条

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