CENTRAL DOPAMINERGIC TRANSMISSION IS SELECTIVELY INCREASED IN THE LIMBIC SYSTEM OF RATS CHRONICALLY EXPOSED TO ANTIDEPRESSANTS

被引：59

作者：

DEMONTIS, GM ^{[1
]}

DEVOTO, P ^{[1
]}

GESSA, GL ^{[1
]}

MELONI, D ^{[1
]}

PORCELLA, A ^{[1
]}

SABA, P ^{[1
]}

SERRA, G ^{[1
]}

TAGLIAMONTE, A ^{[1
]}

机构：

[1] UNIV CAGLIARI,DEPT NEUROSCI,I-09100 CAGLIARI,ITALY

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1990年 / 180卷 / 01期

关键词：

Antidepressants; DOPAC (dihydroxyphenylacetic acd); Dopamine D[!sub]1[!/sub] receptors; Dopamine uptake;

D O I：

10.1016/0014-2999(90)90589-X

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Repeated electroconvulsive shock (ECS) exposure produced a decrease of [3H]SCH 23390 binding sites and a reduced response of adenylate cyclase activity to dopamine D-1 receptor stimulation in the rat limbic area analogous to that previously observed in rats chronically treated with imipramine. These effects were completely prevented by the repeated administration of a small dose of α-methyl-p-tyrosine (α-MPT), associated with the tricyclic compound. Increased dopaminergic transmission seems to be involved in the mechanism of antidepressant action. Rats chronically treated with imipramine showed a decrease of dihydroxyphenylacetic acid (DOPAC) concentration restricted to the limbic area. Finally, both imipramine and desipramine blocked the uptake of [3H]dopamine in the limbic system with a 100-fold greater potency than that observed in the basal ganglia. © 1990.

引用

页码：31 / 35

页数：5

共 15 条

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