CYTOMEGALOVIRUS-RELATED AND INTERFERON-RELATED EFFECTS ON HUMAN ENDOTHELIAL-CELLS - CYTOMEGALOVIRUS-INFECTION REDUCES UP-REGULATION OF HLA CLASS-II ANTIGEN EXPRESSION AFTER TREATMENT WITH INTERFERON-GAMMA

被引:70
作者
SCHOLZ, M
HAMANN, A
BLAHETA, RA
AUTH, MKH
ENCKE, A
MARKUS, BH
机构
[1] Department of Surgery, Johann Wolfgang Goethe University, Frankfurt
关键词
D O I
10.1016/0198-8859(92)90004-7
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Cultured human umbilical vein endothelial cells (HUVEs) were infected with human cytomegalovirus (HCMV) strain AD 169. Up to 5 0% HUVEs proved to be positive for HCMV early nuclear antigens 24 hours after inoculation with virus. Following infection kinetics of surface expression of HLA class I and II, intercellular adhesion molecule (ICAM-1) and endothelial lymphocyte adhesion molecule (ELAM-1) on HUVEs were investigated by means of flow cytometry. A slight increase in HLA class I expression was observed, whereas expression of HLA class II (DR, DP, DQ) antigens was not induced by infection with HCMV. Furthermore, when compared with uninfected cells treated with interferon-gamma (IFN-gamma), reduced enhancement of HLA-DR expression was conspicuous in HCMV-infected cells treated with IFN-gamma. There is evidence that only a portion of HUVE is affected in its ability to upregulate HLA class II antigens. While expression of ICAM-1 was found to be enhanced between 8 and 20 hours after infection with a maximum at 12 hours after infection, no modulation of ELAM-I was seen.
引用
收藏
页码:230 / 238
页数:9
相关论文
共 56 条
  • [21] BETA-2 MICROGLOBULIN ENHANCES THE INFECTIVITY OF CYTOMEGALOVIRUS AND WHEN BOUND TO THE VIRUS ENABLES CLASS-I HLA MOLECULES TO BE USED AS A VIRUS RECEPTOR
    GRUNDY, JE
    MCKEATING, JA
    WARD, PJ
    SANDERSON, AR
    GRIFFITHS, PD
    [J]. JOURNAL OF GENERAL VIROLOGY, 1987, 68 : 793 - 803
  • [22] GRUNDY JE, 1991, TRANSPL P, V23, P38
  • [23] REGULATION OF CELLULAR GENE-EXPRESSION BY INTERFERON-GAMMA - INVOLVEMENT OF MULTIPLE PATHWAYS
    GUPTA, SL
    [J]. INTERNATIONAL JOURNAL OF CELL CLONING, 1990, 8 : 92 - 102
  • [24] CYTOMEGALOVIRUS-INDUCED REGULATION OF MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-I ANTIGEN EXPRESSION IN HUMAN AORTIC SMOOTH-MUSCLE CELLS
    HOSENPUD, JD
    CHOU, SW
    WAGNER, CR
    [J]. TRANSPLANTATION, 1991, 52 (05) : 896 - 903
  • [25] CULTURE OF HUMAN ENDOTHELIAL CELLS DERIVED FROM UMBILICAL VEINS - IDENTIFICATION BY MORPHOLOGIC AND IMMUNOLOGICAL CRITERIA
    JAFFE, EA
    NACHMAN, RL
    BECKER, CG
    MINICK, CR
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1973, 52 (11) : 2745 - 2756
  • [26] KLEMOLA E, 1992, IN PRESS ANN INTERN, V71, P11
  • [27] LAMPSON LA, 1980, J IMMUNOL, V125, P293
  • [28] 3 DISTINCT CLASSES OF REGULATORY CYTOKINES CONTROL ENDOTHELIAL-CELL MHC ANTIGEN EXPRESSION - INTERACTIONS WITH IMMUNE GAMMA-INTERFERON DIFFERENTIATE THE EFFECTS OF TUMOR NECROSIS FACTOR AND LYMPHOTOXIN FROM THOSE OF LEUKOCYTE-ALPHA AND FIBROBLAST-BETA INTERFERONS
    LAPIERRE, LA
    FIERS, W
    POBER, JS
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1988, 167 (03) : 794 - 804
  • [29] HLA-ANTIGEN EXPRESSION ON CULTURED HUMAN ARTERIAL ENDOTHELIAL-CELLS
    MARKUS, BH
    COLSON, YL
    FUNG, JJ
    ZEEVI, A
    DUQUESNOY, RJ
    [J]. TISSUE ANTIGENS, 1988, 32 (05): : 241 - 253
  • [30] MARKUS BH, 1991, CHIRURGISCHES FORUM