A NEW METHOD FOR THE SYNTHESIS OF N-EPSILON-ACETYL-N-EPSILON-HYDROXY-L-LYSINE, THE IRON-BINDING CONSTITUENT OF SEVERAL IMPORTANT SIDEROPHORES

被引：34

作者：

HU, JD ^{[1
]}

MILLER, MJ ^{[1
]}

机构：

[1] UNIV NOTRE DAME, DEPT CHEM & BIOCHEM, NOTRE DAME, IN 46556 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1994年 / 59卷 / 17期

关键词：

D O I：

10.1021/jo00096a030

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Oxidation of the <epsilon)-amino group of N(a)lpha-(carbobenzyloxy)-L-lysine methyl ester with dimethyldioxirane in acetone gave the acetone-derived nitrone of the desired hydroxylamine. Acidic hydrolysis, acetylation, and subsequent deprotection provided a short synthesis of N-epsilon-acetyl-N-epsilon-hydroxy-L-lysine, the iron-binding constituent of important microbial siderophores.

引用

页码：4858 / 4861

页数：4

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