FIBRONECTIN AND TENASCIN IN RAT TRACHEAL WOUND-HEALING AND THEIR RELATION TO CELL-PROLIFERATION

被引：24

作者：

KANNO, S ^{[1
]}

FUKUDA, Y ^{[1
]}

机构：

[1] NIPPON MED COLL,DEPT SURG,TOKYO,TOKYO,JAPAN

来源：

PATHOLOGY INTERNATIONAL | 1994年 / 44卷 / 02期

关键词：

CELL PROLIFERATION; FIBRONECTIN; TENASCIN; WOUND HEALING IN TRACHEA;

D O I：

10.1111/j.1440-1827.1994.tb01693.x

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

To investigate the relationship between cell proliferation and distribution of fibronectin and tenascin during wound healing, light and electron microscopy and immunohistochemistry for fibronectin, tenascin, and B-bromodeoxyuridine (BrdU) were performed following mechanical injury of rat trachea. Tenascin staining appeared 18h after curettage, when the percentage of BrdU-positive nuclei was maximal in the epithelium. Once tenascin appeared, the labeling index of BrdU-positive epithelial nuclei decreased rapidly. Distribution of tenascin was restricted to granulation tissue in curetted areas which were covered with regenerating epithelium, white fibronectin stained diffusely in both curetted and non-curetted areas. Analysis of the relative intensity of fibronectin and tenascin staining showed that decreases of fibronectin staining were followed by increasing tenascin staining. It is proposed that fibronectin and tenascin may contribute differently to tissue repair in the trachea by interfering with cell proliferation of epithelial eels and fibroblasts.

引用

页码：96 / 106

页数：11

共 32 条

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