OXIDATION OF THE METHYL-GROUPS OF N,N-DIMETHYLBENZAMIDES BY A CYTOCHROME P450 MONO-OXYGENASE MODEL SYSTEM

被引：9

作者：

ILEY, J ^{[1
]}

CONSTANTINO, L ^{[1
]}

NORBERTO, F ^{[1
]}

ROSA, E ^{[1
]}

机构：

[1] FAC FARM LISBOA,CECF,INST NACL INVEST CIENTIFICA,P-1699 LISBON,PORTUGAL

来源：

TETRAHEDRON LETTERS | 1990年 / 31卷 / 34期

关键词：

D O I：

10.1016/S0040-4039(00)97769-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Oxidation of N,N-dimethylbenzamides to the corresponding N-formyl-N-methylbenzamides using tetraphenylporphyrinato-iron(III)-ButOOH is independent of the substituent in the aryl ring of the benzamide group and subject to a kinetic deuterium isotope effect of 5.6. These results are consistent with a mechanism involving direct hydrogen atom abstraction from the substrate. © 1990.

引用

页码：4921 / 4922

页数：2

共 8 条

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