PHOTOSENSITIZING ACTION OF FUROCOUMARINS ON MEMBRANE-COMPONENTS AND CONSEQUENT INTRACELLULAR EVENTS

被引:61
作者
DALLACQUA, F
MARTELLI, P
机构
[1] CNR, CTR CHIM FARMACO & PRODOTTI BIOLOGICAMENTE ATTIVI, I-35131 PADUA, ITALY
[2] UNIV SIENA, INST BIOL CHEM, I-53100 SIENA, ITALY
关键词
FUROCOUMARINS; PHOTOSENSITIZATION; MEMBRANE COMPONENTS; RECEPTORS; 2ND MESSENGERS;
D O I
10.1016/1011-1344(91)80082-S
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The photodamage induced in membrane components by furocoumarins is reviewed. The oxygen-dependent photoreactions between furocoumarins and cell membrane constituents lead mainly to lipid peroxidation and the formation of cross-linking in ghost proteins, whereas the oxygen-independent photoreactions lead essentially to a C4 cycloaddition between the furocoumarin and the unsaturated fatty acids. In the latter, cycloadducts are formed between the 3,4 double bond of the furocoumarin and the olefinic double bond of the unsaturated fatty acid. The stereochemical structures of these cycloadducts and the reaction mechanism of the cycloaddition are discussed. Finally, the modulation of several membrane systems by furocoumarins and the consequent intracellular events are reviewed.
引用
收藏
页码:235 / 254
页数:20
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