CELL-PROLIFERATION AND VASCULARIZATION IN HUMAN BREAST CARCINOMAS

被引:25
作者
MONSCHKE, F [1 ]
MULLER, WU [1 ]
WINKLER, U [1 ]
STREFFER, C [1 ]
机构
[1] UNIV ESSEN GESAMTHSCH KLINIKUM,ZENTRUM FRAUENHEILKUNDE,GYNAKOL INSBESONDERE GYNAKOL ONKOL ABT,W-4300 ESSEN 1,GERMANY
关键词
D O I
10.1002/ijc.2910490603
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Cell proliferation and vascularization were studied in 10 human breast carcinomas by an immunoenzyme technique. The monoclonal antibody (MAb) Ki-67 was used as a marker for proliferating cells and a polyclonal antibody directed against human von-Willebrand factor to identify blood vessels. The proportion of Ki-67-labelled cells varied from 1% to 20%, the number of small blood vessels from 4.4/mm2 to 57.6/mm2. Within single histological sections of individual tumours the percentage of proliferating cells was not related to the number of small blood vessels. However, after evaluation of 5 sections of each tumour, the average values showed that tumours with a high grade of vascularization had a higher percentage of Ki-67-positive cells than poorly vascularized samples. The influence of vascular density on cell proliferation was investigated in a selected area of one of the tumours (in 2-dimensions) and with regard to the over- and underlying sections (in 3-dimensions). After 2-dimensional evaluation, distances from proliferating cells to the closest blood vessel between 10 and 390-mu-m were observed, and after 3-dimensional evaluation none of the proliferating cells measured was located more than 130-mu-m away from the closest vessel.
引用
收藏
页码:812 / 815
页数:4
相关论文
共 20 条
[1]   OXYGEN-TENSION PROFILES IN TUMORS PREDICTED BY A DIFFUSION WITH ABSORPTION-MODEL INVOLVING A MOVING FREE-BOUNDARY [J].
ARVE, BH ;
LIAPIS, AI .
MATHEMATICAL AND COMPUTER MODELLING, 1988, 10 (03) :159-174
[2]  
BRAMMER I, 1979, EUR J CANCER, V13, P1329
[3]  
BURSTONE MS, 1958, J NATL CANCER I, V20, P601
[4]   PRODUCTION OF A MOUSE MONOCLONAL-ANTIBODY REACTIVE WITH A HUMAN NUCLEAR ANTIGEN ASSOCIATED WITH CELL-PROLIFERATION [J].
GERDES, J ;
SCHWAB, U ;
LEMKE, H ;
STEIN, H .
INTERNATIONAL JOURNAL OF CANCER, 1983, 31 (01) :13-20
[5]   ON THE ACCESS OF BLOOD-BORNE DYES TO VARIOUS TUMOUR REGIONS [J].
GOLDACRE, RJ ;
SYLVEN, B .
BRITISH JOURNAL OF CANCER, 1962, 16 (02) :306-322
[6]   EARLY STAGES OF ABSORPTION OF INJECTED HORSERADISH PEROXIDASE IN PROXIMAL TUBULES OF MOUSE KIDNEY - ULTRASTRUCTURAL CYTOCHEMISTRY BY A NEW TECHNIQUE [J].
GRAHAM, RC ;
KARNOVSKY, MJ .
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 1966, 14 (04) :291-+
[7]  
Hall E.J, 1978, RADIOBIOLOGY RADIOLO, V1st
[8]   TUMOR-CELL PROLIFERATION IN RELATION TO VASCULATURE [J].
HIRST, DG ;
DENEKAMP, J .
CELL AND TISSUE KINETICS, 1979, 12 (01) :31-42
[9]  
JONES B, 1983, CELL TISSUE KINET, V16, P351
[10]  
KAMEL OW, 1989, AM J PATHOL, V134, P107