IODIDE-INDUCED HYPO-THYROIDISM - POTENTIAL HAZARD DURING PERINATAL LIFE

被引：99

作者：

THEODOROPOULOS, T

BRAVERMAN, LE

VAGENAKIS, AG

机构：

来源：

SCIENCE | 1979年 / 205卷 / 4405期

关键词：

D O I：

10.1126/science.451615

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The administration of iodide to pregnant and nursing rats induces hypothyroidism in the term fetus and neonatal rat through age 10 days as indicated by an increase in the serum concentration of thyroid-stimulating hormone and a decrease in the serum of thyroxine and triiodothyronine. Thyroid function returned to normal from age 18 through 60 days in spite of continued iodide administration, strongly suggesting that resistance to the inhibitory effect of iodide on thyroid hormone synthesis is developed at approximately 18 days of age. This perinatal rat model can be used to study the mechanisms responsible for iodide-induced hypothyroidism and goiter in human newborns whose mothers received iodide-containing medications during pregnancy. Copyright © 1979 AAAS.

引用

页码：502 / 503

页数：2

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